Allele and genotype | Populations | OR | I 2 (%) | P heterogeneity | Analysis model | P |
---|---|---|---|---|---|---|
326Cys allele versus 326Ser allele (additive model) a | All populations | 1.06 (0.90, 1.26) | 64% | 0.01 | Random | 0.49 |
Caucasian populations | 0.95 (0.85, 1.06) | 30% | 0.23 | Fixed | 0.38 | |
Asian populations | 1.14 (0.82, 1.57) | 75% | 0.02 | Random | 0.44 | |
Hospital-based | 1.00 (0.90, 1.11) | 51% | 0.07 | Random | 0.99 | |
Studies in HWE | 1.01 (0.91, 1.44) | 65% | 0.02 | Random | 0.83 | |
Cys/Cys versus Ser/Ser (homozygote contrast) a | All populations | 1.11 (0.74, 1.66) | 65% | 0.009 | Random | 0.63 |
Caucasian populations | 0.87 (0.66, 1.16) | 0% | 0.41 | Fixed | 0.35 | |
Asian populations | 1.34 (0.64, 2.83) | 78% | 0.01 | Random | 0.44 | |
Hospital-based | 0.97 (0.65, 1.45) | 54% | 0.06 | Random | 0.89 | |
Studies in HWE | 1.12 (0.71, 1.79) | 71% | 0.004 | Random | 0.62 | |
Cys/Cys versus Cys/Ser + Ser/Ser (recessive genetic model)a | All populations | 1.05 (0.65, 1.70) | 79% | <0.0001 | Random | 0.85 |
Caucasian populations | 0.85 (0.65, 1.21) | 25% | 0.26 | Fixed | 0.25 | |
Asian populations | 1.26 (0.50, 3.17) | 89% | <0.0001 | Random | 0.62 | |
Hospital-based | 0.89 (0.57, 1.38) | 66% | 0.01 | Random | 0.59 | |
Studies in HWE | 1.14 (0.67, 1.94) | 81% | <0.0001 | Random | 0.64 | |
Cys/Cys + Cys/Ser versus Ser/Ser (dominant genetic model) a | All populations | 1.07 (0.87, 1.32) | 58% | 0.03 | Random | 0.53 |
Caucasian populations | 1.04 (0.74, 1.47) | 75% | 0.007 | Random | 0.82 | |
Asian populations | 1.16 (0.91, 1.47) | 0% | 0.85 | Fixed | 0.23 | |
Hospital-based | 1.07 (0.83, 1.36) | 64% | 0.02 | Random | 0.61 | |
Studies in HWE | 0.97 (0.86, 1.09) | 0% | 0.45 | Fixed | 0.59 |