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Table 5 Summary of efficacy results

From: Peri-operative chemotherapy in the management of resectable colorectal cancer pulmonary metastases

  Total cohort Peri-operative chemotherapy Surgery alone
  n = 51 n = 38 n = 13
Number of patients 51 38 13
Disease-free interval (range) 24.1 months 20.5 months 27.5 months
  (2.8-64.1) (11.7-64.1) (2.8-52.8)
Overall survival    
Median (95% CI) 77 months (55–99) 91 months (61–121) 67 months (39–96)
3-year (95% CI) 86% (72–93) 85% (68–93) 87% (56–96)
5-year (95% CI) 72% (55–83) 74% (54–86) 68% (35–87)
Relapse free survival    
Median (95% CI) 29 months (18–39) 30 months (0–68) 21 months (13–30)
3-year (95% CI) 42% (28–55) 46% (29–61) 38% (12–56)
5-year (95% CI) 31% (18–45) 33% (22–54) ≤18%*
Response to neoadjuvant chemotherapy
   n = 39 resections  
Complete response   0  
Tumour reduction   23 (62%)  
Stable disease   11 (30%)  
Disease control   34 (92%)  
Tumour progression   3 (8%)  
No scans available   2  
  1. *Not estimable as no events occurred at year 5 and only 1 patient left at risk at year 4 where RFS was estimated at 18%.