Table 2 Adverse events in patients with advanced non-small cell lung cancer treated with erlotinib and pemetrexed
Level 1 (n = 6) | Level 2 (n = 6) | |||||||
|---|---|---|---|---|---|---|---|---|
Hematologic | G1 | G2 | G3 | G4 | G1 | G2 | G3 | G4 |
Neutropenia/Leukopenia | 2 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
Thrombocytopenia | 2 | 1 | 0 | 0 | 1 | 1 | 0 | 0 |
Anemia | 3 | 3 | 0 | 0 | 4 | 1 | 0 | 0 |
Non-Hematologic | G1 | G2 | G3 | G4 | G1 | G2 | G3 | G4 |
Nausea | 3 | 0 | 0 | 0 | 2 | 1 | 0 | 0 |
Vomit | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Anorexia | 3 | 1 | 0 | 0 | 2 | 1 | 0 | 0 |
Malaise | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Fatigue | 2 | 1 | 0 | 0 | 3 | 0 | 0 | 0 |
Diarrhea | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Constipation | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 0 |
Hiccup | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Oral mucositis | 1 | 0 | 0 | 0 | 3 | 0 | 0 | 0 |
Rash | 2 | 2 | 1 | 0 | 1 | 5 | 0 | 0 |
Pruritus | 1 | 0 | 1 | 0 | 2 | 0 | 1 | 0 |
Paronychia | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 |
Alopecia | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Peripheral Edema | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Alb | 4 | 1 | 0 | 0 | 1 | 2 | 0 | 0 |
AST | 4 | 2 | 0 | 0 | 3 | 1 | 0 | 0 |
ALT | 0 | 3 | 1 | 0 | 2 | 2 | 0 | 0 |
ALP | 2 | 0 | 0 | 0 | 2 | 1 | 0 | 0 |
Bilirubin | 1 | 0 | 0 | 0 | 2 | 1 | 0 | 0 |
Na | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 |
K | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |