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Table 3 A multivariate model in which each miRNA was analyzed individually together with differentiation grade as a predictor for PFS in wild-type- KRAS and mutated- KRAS patients treated with chemotherapy, bevacizumab and cetuximab

From: Beyond KRAS mutation status: influence of KRAScopy number status and microRNAs on clinical outcome to cetuximab in metastatic colorectal cancer patients

   Overall n = 32 KRAS wild-type n = 18 KRAS mutation n = 14 p-value
MiR-27b HR (95% CI) 0.74 (0.38-1.42) 0.94 (0.36-2.42) 0.51 (0.20-1.32) 0.38
p-value 0.36 0.89 0.16
MiR-105 HR (95% CI) 1.04 (0.84-1.29) 0.95 (0.76-1.21) 1.22 (0.83-1.78) 0.26
p-value 0.72 0.69 0.32
MiR-155 HR (95% CI) 0.92 (0.62-1.35) 0.77 (0.38-1.53) 0.96 (0.60-1.51) 0.60
p-value 0.66 0.45 0.85
MiR-346 HR (95% CI) 0.83 (0.63-1.10) 0.85 (0.61-1.19) 0.72 (0.40-1.32) 0.63
p-value 0.20 0.34 0.29
MiR-181a HR (95% CI) 0.75 (0.46-1.22) 0.70 (0.37-1.33) 0.94 (0.44-2.02) 0.57
p-value 0.24 0.27 0.87
MiR-19a HR (95% CI) 0.96 (0.78-1.19) 1.03 (0.80-1.33) 0.74 (0.45-1.20) 0.23
p-value 0.73 0.82 0.22
MiR-200b HR (95% CI) 1.03 (0.72-1.47) 0.90 (0.51-1.57) 1.78 (0.87-3.62) 0.18
p-value 0.86 0.70 0.10
MiR-27a HR (95% CI) 0.74 (0.43-1.27) 0.69 (0.31-1.54) 0.71 (0.35-1.43) 0.96
p-value 0.27 0.37 0.34
MiR-30a HR (95% CI) 0.70 (0.44-1.10) 0.77 (0.40-1.55) 0.70 (0.37-1.34) 0.86
p-value 0.12 0.46 0.28
Let-7a HR (95% CI) 0.94 (0.59-1.50) 0.89 (0.50-1.59) 1.28 (0.46-3.58) 0.55
p-value 0.80 0.68 0.63
MiR-21 HR (95% CI) 0.89 (0.57-1.39) 1.15 (0.52-2.55) 0.81 (0.49-1.33) 0.47
p-value 0.61 0.74 0.40
MiR-96 HR (95% CI) 0.84 (0.59-1.20) 0.74 (0.45-1.22) 0.93 (0.55-1.58) 0.54
p-value 0.33 0.24 0.79
MiR-143 HR (95% CI) 0.73 (0.51-1.05) 0.92 (0.56-1.51) 0.63 (0.40-0.99) 0.26
p-value 0.09 0.74 0.04
MiR-217 HR (95% CI) 1.01 (0.87-1.16) 0.85 (0.61-1.19) 0.78 (0.56-1.08) 0.72
p-value 0.95 0.34 0.13
MiR-133a HR (95% CI) 0.81 (0.63-1.05) 0.98 (0.68-1.43) 0.66 (0.41-1.06) 0.21
p-value 0.12 0.92 0.09
MiR-133b HR (95% CI) 0.89 (0.70-1.13) 1.04 (0.73-1.49) 0.80 (0.55-1.17) 0.32
p-value 0.32 0.83 0.25
MiR-19b HR (95% CI) 0.95 (0.75-1.20) 1.02 (0.77-1.34) 0.66 (0.36-1.23) 0.21
p-value 0.65 0.91 0.19