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Table 1 Characteristics of case–control studies of hepatitis viruses infection and ICC risk

From: Hepatitis viruses infection and risk of intrahepatic cholangiocarcinoma: evidence from a meta-analysis

First author Year Country Cases
(n)
Control
(n)
Control description OR (95% CI)
for HBV infection
OR (95% CI)
for HCV infection
Study quality
Parkin 1991 Thailand 100 100 Hospital-based control 1.0 (0.4-2.1) 1
Shin 1996 Korea 41 406 Hospital-based control 1.3 (0.3-5.3) 3.9 (0.9-17.1) 2
Donato 2001 Italy 26 824 Hospital-based control 2.7 (0.4-18.5) 9.7 (1.6-58.9) 2
Yamamoto 2004 Japan 50 205 Hospital-based control 1.8 (0.3-10.1) 16.8 (5.7-50.0) 2
Shaib 2005 US 625 90834 Population-based control 0.8 (0.1-5.9) 6.1 (4.3-8.6) 2
Choi 2006 Korea 185 185 Hospital-based control 0.8 (0.198-3.023) 1.0(0.04-25.264) 2
Shaib 2007 US 83 236 Hospital-based control 2.9 (0.1-236.8) 7.9 (1.3-84.5) 2
Welzel 2007 US 535 102782 Population based control 4.4 (1.4-14.0) 1
Lee 2008 Korea 622 2488 Hospital-based control 2.3 (1.6-3.3) 1.0 (0.5-1.9) 2
Zhou 2008 China 312 438 Hospital-based control 8.876 (5.98-13.19) 0.933 (0.281-3.1) 2
Lee 2009 Taiwan 160 160 Hospital-based control 4.985 (2.78-8.95) 2.71 (1.16-6.32) 2
Tao 2010 China 61 380 Hospital-based control 18.1 (7.5-44.0) 1
Peng 2011 China 98 196 Hospital-based control 2.75 (1.27-5.95) 1
  1. ICC, intrahepatic cholangiocarcinoma; HBV,hepatitis B virus; HCV, hepatitis C virus; US, United States.