Figure 7From: Phosphorylation of transglutaminase 2 (TG2) at serine-216 has a role in TG2 mediated activation of nuclear factor-kappa B and in the downregulation of PTEN Schematic diagram showing potential mechanism involved in tumor promoting function of TG2. We propose that depending on upstream stimuli TG2 contribute to Akt activation in a PTEN-dependent and -independent manner.Back to article page