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Table 3 Stratification analysis of colorectal cancer risk associated with ESR2 genotypes

From: Association of estrogen receptor betavariants and serum levels of estradiol with risk of colorectal cancer: a case control study

  rs1256049    rs4986938
  CC (Ref.a) CT/TT   CC (Ref.a) CT/TT  
Subgroups Ca/Cob Ca/Cob ORc (95% CI) Ca/Cob Ca/Cob ORc (95% CI)
Age, years
 ≤ 48 30/88 50/150 1.0 (0.5–1.8) 55/186 27/49 1.4 (0.7–2.7)
 >48 138/79 165/124 0.7 (0.5–1.0) 222/163 82/39 1.5 (0.9–2.3)
P interaction    0.483    0.831
 Ever 88/104 87/175 0.5 (0.4–0.8) 139/226 40/53 1.0 (0.6–1.7)
 Never 80/63 128/162 1.0 (0.6–1.6) 138/123 69/35 2.2 (1.3–4.0)
P interaction    0.061    0.058
Alcohol drinking status
 Ever 66/112 66/178 0.6 (0.4–1.0) 100/229 34/57 1.6 (0.9–2.7)
 Never 89/123 55/96 0.8 (0.5–1.2) 148/120 66/31 1.5 (0.9–2.4)
P interaction    0.473    0.651
  1. aRef. = reference group.
  2. bCa/Co = colorectal cancer cases/controls.
  3. cORs were calculated using unconditional logistic regression model adjusted for age, smoking status and alcohol drinking status.