Table 3 Stratification analysis of colorectal cancer risk associated with ESR2 genotypes

Age, years

 ≤ 48

30/88

50/150

1.0 (0.5–1.8)

55/186

27/49

1.4 (0.7–2.7)

 >48

138/79

165/124

0.7 (0.5–1.0)

222/163

82/39

1.5 (0.9–2.3)

 P _interaction

0.483

0.831

 Ever

88/104

87/175

0.5 (0.4–0.8)

139/226

40/53

1.0 (0.6–1.7)

 Never

80/63

128/162

1.0 (0.6–1.6)

138/123

69/35

2.2 (1.3–4.0)

 P _interaction

0.061

0.058

Alcohol drinking status

 Ever

66/112

66/178

0.6 (0.4–1.0)

100/229

34/57

1.6 (0.9–2.7)

 Never

89/123

55/96

0.8 (0.5–1.2)

148/120

66/31

1.5 (0.9–2.4)

 P _interaction

0.473

0.651