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Table 4 The relationship between the IGF and ER mRNA expression and clinico-pathological features of endometrioid adenocarcinoma

From: Insulin-like growth factors in endometrioid adenocarcinoma: Correlation with clinico-pathological features and estrogen receptor expression

Clinical pathology (n)

IGF-1

IGF-2

IGF-1R

IGF-2R

IGFBP-3

ERα

ERβ

Surgico-pathological stage

I(33)

1.70 ± 0.73

3.28 ± 2.17

1.62 ± 0.86

4.97 ± 2.77

14.91 ± 13.03

16.57 ± 4.1

42.04 ± 23.28

II(15)

0.58 ± 0.09*

1.73 ± 2.47

1.84 ± 0.96

4.70 ± 2.96*

13.25 ± 13.32

4.33 ± 2.39*

25.70 ± 24.47*

 

III(10)

0.44 ± 0.02#

0.72 ± 1.31#

1.50 ± 0.79

1.60 ± 2.50#

14.83 ± 16.79

0.72 ± 0.33#

5.07 ± 2.11#

Histological grade

G1(14)

1.44 ± 0.24

3.25 ± 2.27

1.53 ± 1.92

4.75 ± 3.01

16.22 ± 14.47

16.85 ± 4.37

41.93 ± 26.78

G2(31)

1.39 ± 0.95$

2.53 ± 2.38$

1.32 ± 0.99

4.92 ± 2.63$

11.78 ± 11.27

11.70 ± 6.94$

35.08 ± 23.96$

 

G2(13)

0.47 ± 0.07&

1.34 ± 2.02&

1.66 ± 0.84

2.42 ± 3.27&

18.99 ± 16.87

1.55 ± 1.79&

11.47 ± 16.42&

Depth of myometrial invasion

≤ 50%(39)

1.47 ± 0.79

3.14 ± 2.27

1.55 ± 0.90

5.26 ± 2.68

15.82 ± 12.78

14.28 ± 5.64

41.48 ± 24.10

 

>50%(19)

0.63 ± 0.46@

0.98 ± 1.76@

1.15 ± 0.78

2.39 ± 2.75@

11.69 ± 15.01

3.26 ± 5.86@

10.83 ± 12.55@

  1. p < 0.05 stage I vs stage II;*P < 0.05 stage II vs stage III; #P < 0.05 stage I vs stage III;P < 0.05 G1 vs G2;$P < 0.05 G2 vs G3;&P < 0.05 G1 vs G3;@P < 0.05 vs ≤50% of mymetrial invasion by one-way ANOVA.