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Table 4 Performance comparison between HE4 and CA125 for EOC and OC prediction

From: Does risk for ovarian malignancy algorithm excel human epididymis protein 4 and ca125 in predicting epithelial ovarian cancer: A meta-analysis

Settings (study numbers) [analysis model] Mean Sen (95% CI) Mean Spe (95% CI) Mean DOR (95% CI) Mean LR+ (95% CI) Mean LR- (95% CI) AUC (95% CI)
EOC EOC- HE4 (n = 4) [bi] 0.79 (0.74-0.84) 0.93 (0.87-0.96) 47.59 (23.87-94.90) 10.64 (5.93-19.10) 0.22 (0.17-0.29) 0.82 (0.78-0.85) #
   [I2 =0.0%] # [I2 =72.0%] [I2 =41.3%] [I2 =71.3%] [I2 =0.0%]  
  EOC-CA125 (n = 4) [bi] 0.77 (0.58-0.89) 0.84 (0.76-0.90) 18.86 (10.22-31.21) 4.90 (3.63-6.61) 0.27 (0.15-0.50) 0.88 (0.85-0.91)
   [I2 =90.2%] [I2 =85.3%] [I2 =57.4%] [I2 =56.2%] [I2 =85.2%]  
OC OC-HE4 (n = 5) [bi] 0.77(0.72-0.81) 0.89 (0.82-0.93) 25.37 (14.58-44.14) 6.66 (4.25-10.43) 0.26 (0.22-0.32) 0.79 (0.76-0.83) #
   [I2 =0.0%] [I2 =58.9%] [I2 =40.7%] [I2 =50.3%] [I2 = 0.0%]  
  OC-CA125 (n = 5) [bi] 0.73 (0.63-0.81) 0.86 (0.81-0.90) 17.12 (11.64-25.19) 5.35 (4.09-7.00) 0.31 (0.23-0.43) 0.89 (0.85-0.91)
   [I2 =80.3%] [I2 =49.4%] [I2 =7.8%] [I2 =0.0%] [I2 =75.2%]  
  1. Sen: sensitivity; spe: specificity; DOR: diagnostic odds ratio; LR+: positive likelihood ratio; LR-: negative likelihood ratio; CI: confidence interval; bi: bivariate model; # compared to CA125 with significant difference (p<0.05). All estimates in OC group have no significant difference (p>0.05) with corresponding estimates in EOC group. I2 for estimates (sen, spe, DOR and LR±) were calculated.