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Table 2 Univariate prognostic factor analysis of advanced non-small cell lung cancer in young adults

From: Advanced non-small cell lung cancer in patients aged 45 years or younger: outcomes and prognostic factors

  Hazard Ratio (95% confidence interval) p value
Age > 40 years 1.00 (0.67–1.48) 0.99
Male gender 1.25 (0.85–1.82) 0.26
BMI < 25 kg/m2 2.82 (1.52–5.26) 0.001
Smoking history 0.96 (0.65–1.41) 0.83
Medical co-morbidity 1.26 (0.55–2.89) 0.58
Clinical stage   
IIIB 1  
IV 2.24 (1.43–3.49) <0.001
Performance status   
0-1 1  
2-4 1.59 (1.04–2.43) 0.03
Histology   
Adenocarcinoma 1  
Squamous cell carcinoma 1.02 (0.41–2.52) 0.97
Undifferentiated 1.26 (0.67–2.37) 0.47
Laboratory data at diagnosis   
Anemia (hemoglobin < 11 g/dL) 2.44 (1.45–4.10) 0.001
Leukocytosis (>10,000 cells/μL) 2.72 (1.75–4.21) <0.001
Thrombocytosis (>400,000 cells/μL) 1.70 (1.00–2.90) 0.05
Hypoalbuminemia (<3.5 g/dL) 3.26 (1.69–6.30) <0.001
Abnormal liver function 1.12 (0.68–1.83) 0.65
Initial treatment modalities   
Chemotherapy 1  
EGFR-TKI therapy 1.14 (0.75–1.71) 0.54
  1. BMI: body mass index; EGFR-TKI: epidermal growth factor receptor-tyrosine kinase inhibitor.