Table 2 Univariate prognostic factor analysis of advanced non-small cell lung cancer in young adults

Age > 40 years

1.00 (0.67–1.48)

Male gender

1.25 (0.85–1.82)

BMI < 25 kg/m²

2.82 (1.52–5.26)

Smoking history

0.96 (0.65–1.41)

Medical co-morbidity

1.26 (0.55–2.89)

Clinical stage

IIIB

1

IV

2.24 (1.43–3.49)

Performance status

0-1

1

2-4

1.59 (1.04–2.43)

Histology

Adenocarcinoma

1

Squamous cell carcinoma

1.02 (0.41–2.52)

Undifferentiated

1.26 (0.67–2.37)

Laboratory data at diagnosis

Anemia (hemoglobin < 11 g/dL)

2.44 (1.45–4.10)

Leukocytosis (>10,000 cells/μL)

2.72 (1.75–4.21)

Thrombocytosis (>400,000 cells/μL)

1.70 (1.00–2.90)

Hypoalbuminemia (<3.5 g/dL)

3.26 (1.69–6.30)

Abnormal liver function

1.12 (0.68–1.83)

Initial treatment modalities

Chemotherapy

1

EGFR-TKI therapy

1.14 (0.75–1.71)