Figure 1
From: Transforming growth factor-β suppresses metastasis in a subset of human colon carcinoma cells
Orthotopic implantation of xenografts formed by FETα and FETα-DN cells are shown. (A) Fluorescent images of isolated primary tumors and lungs from FETα orthotopically implanted animals. Green fluorescence reflects colony formation. Note the lack of fluorescent nodules. (B) Fluorescent images of isolated primary tumors and lungs from FETα-DN orthotopically implanted animals. Green fluorescence reflects colony formation. (C) Primary tumors from FETα and FETα-DN orthotopic implants highlighting the leading edge of invasion (top); and of metastases in the lungs of orthotopic FETα-DN implanted animals with H&E staining. Images were captured at 200x magnification.