Figure 5
From: Intracranial melanocytic meningeal tumours and melanosis oculi: case report and literature review
Histological examination. Haematoxylin and eosin staining (A - original magnification: X 300) documenting round or spindled neoplastic cells, with regular nuclei and small nucleoli, with only occasional mitoses (less than 1x10 HPF); melanin pigment is evident in occasional cells. Immunohistochemistry with anti-HMB45 (B) and anti Melan-A (C) antibodies documented a variable but substantial proportion of labelled neoplastic cells (original magnification: X 300). MIB1/Ki67 immunohistochemistry (D) documented only a low percentage of labelled neoplastic cells (mean: 3 %) (original magnification: X 250).