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Table 2 Chronologic synopsis of case report

From: Late onset Li-Fraumeni Syndrome with bilateral breast cancer and other malignancies: case report and review of the literature

Year / Month

Sarcoma/Carcinoma

Stage

Therapy

Follow up

2006/08 (40 y)

Myxofibro-sarcoma right upper arm

pT1a, pNx, pMx, G2, R0

Incomplete resection, R1, 2006/08

palpation,

   

Re-Resection, R1, 2006/09

12-mo MRI

   

Re-Re-Resection with musculo-cutaneous flap 2006/11

 

2006/12 (40 y)

Breast cancer right side

ypT2 ypN1a (2/13) yM0 L0 V0 R0 yG3, ER IRS 2, PR IRS 9, Her2neu pos., IRS 3, invasive ductal carcinoma

Neo-adj. CT with 4x FEC, 2007/01-04,

prophylactic

   

Lumpectomy and axillary dissection 2007/05,

mastectomy offered

   

Adj. CT, 4x P 2007/06-08,

3-mo palpation,

   

Herceptin® 2007/09-2008/06

6-mo ultrasound,

   

GnRH Analoga + TAM 07/09-ongoing

12-mo MRI

2006/12 (40 y)

Breast cancer left side

ypT1c ypN1mic (1/17) yM0 L0 V0 R0 yG3, ER IRS 8, PR IRS 12, Her2neu pos. IRS 3, invasive ductal carcinoma

see above

see above

2007/05 (40 y)

Liposarcoma periadrenal left

pT2b pN0 (0/2 LK) pMx L0 V0 G3, Rx, pleomorph sarcoma

Lumbal left adrenalectomy 2007/05,

MRI

   

Radiation therapy (66 Gy) 2007/08-10

 

2008/05 (41 y)

Recurrence Recurrence

ypT2 ypN0 (0/14) ypMx G1 R1(vessel)

CT with 2xIfos 2008/06, followed by Trabectedin, Mini-ICE and Hyperthermia 2009/01-05

 
   

Compartment resection with hemicolectomy, splenectomy, partial diaphragm resection and resection of 11th costa 2009/06

 

2010/06

Recurrence

 

CT with Trabectedin since 2010/06

 
  1. Abbreviations: Neo-adj. = neo-adjuvant, Adj. = adjuvant, CT = Chemotherapy, FEC = 5-FU 500 mg/², Epirubicine 100 mg/m², Cyclophosphamide 500 mg/m², q21d, P = Paclitaxel 175 mg/m², q21d, TAM = Tamoxifen®, Ifos = Ifosfamide, mo = monthly, Mini-ICE = Ifosfamid, Carboplatin, Etoposide.