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Figure 2 | BMC Cancer

Figure 2

From: Penetration of anticancer drugs through tumour tissue as a function of cellular packing density and interstitial fluid pressure and its modification by bortezomib

Figure 2

Influence of bortezomib pre-treatment on sensitivity to doxorubicin or gemcitabine in monolayers (panels A and C) or MCC (panels B and D) derived from HCT-8Ea (panels A and B) or HCT-8E11cells (panels C and D). Monolayers and MCC were pre-treated with 250 nm or 1 μM bortezomib (BZ) or diluents for 24 h respectively, followed by treatment with doxorubicin (Dox, 10 μM in monolayer or 100 μM in MCC) or gemcitabine (Gem, 20 μM in monolayer or 125 μM in MCC) for 24 h. Data represent the ratio of the number of colonies measured in a given treatment condition to colonies in the untreated condition (mean values from 3 experiments). Bortezomib pre-treatment decreased the cytotoxicity of doxorubicin and gemcitabine for HCT-8Ea cells in monolayer (p = 0.012 and p = 0.001 respectively) but had no significant affect on cytotoxicity of either drug for HCT-8E11 cells (Figure 2, panels A and C).

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BMC Cancer

ISSN: 1471-2407

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