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Table 1 Follicular lymphoma grading according to the WHO classification 1

From: Has the time to come leave the “watch-and-wait” strategy in newly diagnosed asymptomatic follicular lymphoma patients?

Grading Definition

Grade 1–2 (low grade) 0–15 centroblasts per hpf*

· 1 0–5 centroblasts per hpf

· 2 6–15 centroblasts per hpf

Grade 3 >15 centroblasts per hpf

· 3A: centrocytes present

· 3B: solid sheets of centroblasts

Follicular Pattern

· Follicular >75%

· Follicular and diffuse 25–75%

· Focally follicular <25%

· Diffuse 0%**

  1. * hpf = high-power field of 0.159 mm2.
  2. ** Diffuse areas containing >15 centroblasts per hpf are reported as DLBCL with FL (grades 1 to 2, 3A or 3B). Note that in small biopsies the absence of follicles may reflect a sampling error.
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BMC Cancer

ISSN: 1471-2407

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