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Table 3 Effect of 5-Aza-dC on expression of KDR and FLT4

From: DNA methylation regulates expression of VEGF-R2 (KDR) and VEGF-R3 (FLT4)

  KDR FLT4
  mRNA induced by Aza mRNA induced by Aza
CMK pos - pos -
DOHH-2 neg + neg ++
EM-2 neg (+) neg +++
HL-60 neg +++ pos -
L-82 neg - neg +
SC-1 neg ++ neg +
  1. Induction of KDR and FLT4 by 5-Aza-dC (5 μM, 3 d) when compared to untreated control cells: - < 2.5-fold; (+) > 2.5-fold; + > 10-fold; ++ > 40-fold; +++ > 160-fold. Expression levels were determined by qRT-PCR. TBP expression was used as endogenous control, DMSO (0.05%) treated cells were used for normalization