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Table 3 Effect of 5-Aza-dC on expression of KDR and FLT4

From: DNA methylation regulates expression of VEGF-R2 (KDR) and VEGF-R3 (FLT4)

 

KDR

FLT4

 

mRNA

induced by Aza

mRNA

induced by Aza

CMK

pos

-

pos

-

DOHH-2

neg

+

neg

++

EM-2

neg

(+)

neg

+++

HL-60

neg

+++

pos

-

L-82

neg

-

neg

+

SC-1

neg

++

neg

+

  1. Induction of KDR and FLT4 by 5-Aza-dC (5 μM, 3 d) when compared to untreated control cells: - < 2.5-fold; (+) > 2.5-fold; + > 10-fold; ++ > 40-fold; +++ > 160-fold. Expression levels were determined by qRT-PCR. TBP expression was used as endogenous control, DMSO (0.05%) treated cells were used for normalization
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BMC Cancer

ISSN: 1471-2407

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