Figure 6
From: DNA methylation regulates expression of VEGF-R2 (KDR) and VEGF-R3 (FLT4)
Degradation of IκB and phosphorylation of p38MAPK in MALP-2 responsive cell lines. Cell lines EM-2 (FLT4 negative) and OCI-AML1 (FLT4 positive) were stimulated with MALP-2 (100 ng/ml). The NF-κB inhibitor IκB was phosphorylated (7 min) and degraded (7 min, 21 min) in both cell lines. Likewise, rapid phosphorylation of p38 MAPK was observed in both cell lines by Western blot analysis. GAPDH is shown as loading control.