Table 9 Adherence to therapy in premenopausal breast cancer patients treated with tamoxifen or toremifene
|  | Tamoxifen (n = 240) | Toremifene (n = 212) | p value |
|---|---|---|---|
 Total | 45 | 31 | 0.242 |
 Transfer to AIs after menopause | 24 | 15 | 0.269 |
 Discontinuance or other therapy | 21 | 16 | 0.542 |
 Cervical cyst | 1 | 0 |  |
 Uterine fibroids | 1 | 0 |  |
 Ostalgia | 1 | 0 |  |
 Skinrash | 2 | 0 |  |
 Endometrial hyperplasia | 5 | 0 |  |
 In order to be pregnancy | 1 | 1 |  |
 Diarrhea | 1 | 0 |  |
 To fear adverse effect | 1 | 4 |  |
 Economic reason | 1 | 0 |  |
 Transaminase step-up | 1 | 2 |  |
 Chinese traditional medicine | 2 | 0 |  |
 Discontinuance for unknow reasons | 4 | 6 |  |
 Hyper-menorrhea | 0 | 2 |  |
 Vaginal bleeding | 0 | 1 |  |