Table 9 Adherence to therapy in premenopausal breast cancer patients treated with tamoxifen or toremifene
| Tamoxifen (n = 240) | Toremifene (n = 212) | p value | |
|---|---|---|---|
| Total | 45 | 31 | 0.242 |
| Transfer to AIs after menopause | 24 | 15 | 0.269 |
| Discontinuance or other therapy | 21 | 16 | 0.542 |
| Cervical cyst | 1 | 0 | |
| Uterine fibroids | 1 | 0 | |
| Ostalgia | 1 | 0 | |
| Skinrash | 2 | 0 | |
| Endometrial hyperplasia | 5 | 0 | |
| In order to be pregnancy | 1 | 1 | |
| Diarrhea | 1 | 0 | |
| To fear adverse effect | 1 | 4 | |
| Economic reason | 1 | 0 | |
| Transaminase step-up | 1 | 2 | |
| Chinese traditional medicine | 2 | 0 | |
| Discontinuance for unknow reasons | 4 | 6 | |
| Hyper-menorrhea | 0 | 2 | |
| Vaginal bleeding | 0 | 1 |