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Table 8 Side effects and adverse events in premenopausal breast cancer patients treated with tamoxifen or toremifene

From: A comparison of survival outcomes and side effects of toremifene or tamoxifen therapy in premenopausal estrogen and progesterone receptor positive breast cancer patients: a retrospective cohort study

  Tamoxifen Toremifene p value
Subjective    
 Sweating 59 63 0.220
 Hot flash 56 67 0.049
 Vaginal discharge 12 7 0.369
 Leucorrhea increasing 22 31 0.072
 Vaginal dryness 18 13 0.566
 Vaginal bleeding 3 4 0.869
 Skin pruritus 19 18 0.824
 Depression 17 22 0.213
 Skinrash 15 13 0.959
 Nausea or vomit 3 8 0.082
 Diarrhea 3 3 1.000
 Asomnia 22 25 0.361
 Weightgain 50 45 0.918
 Fracture 2 1 1.000
 Ostalgia 49 49 0.488
 Hyper-menorrhea 2 7 0.124
 Blurred vision 5 3 0.857
Objectives    
 Ovarian cysts 12 18 0.137
 Teratoma 1 1 1.000
 Uterine fibroids 25 35 0.057
 Hysterectomy 9 17 0.052
 Uterine polyps 2 3 0.889
 Cervical cyst 2 0 0.501
 Endometrial hyperplasia 15 22 0.110
 Osteoporosis 4 2 0.796
 Fatty liver 25 20 0.728
 Hemangiomas 4 3 1.000
 Hepatic cyst 8 5 0.536
 Cholecystic polips 3 4 0.869
 Transaminase step-up 2 7 0.426
 Splenic hemangioma 0 1 0.469
 Cataracts 0 1 0.469