Table 8 Side effects and adverse events in premenopausal breast cancer patients treated with tamoxifen or toremifene

Subjective

 Sweating

59

63

0.220

 Hot flash

56

67

0.049

 Vaginal discharge

12

7

0.369

 Leucorrhea increasing

22

31

0.072

 Vaginal dryness

18

13

0.566

 Vaginal bleeding

3

4

0.869

 Skin pruritus

19

18

0.824

 Depression

17

22

0.213

 Skinrash

15

13

0.959

 Nausea or vomit

3

8

0.082

 Diarrhea

3

3

1.000

 Asomnia

22

25

0.361

 Weightgain

50

45

0.918

 Fracture

2

1

1.000

 Ostalgia

49

49

0.488

 Hyper-menorrhea

2

7

0.124

 Blurred vision

5

3

0.857

Objectives

 Ovarian cysts

12

18

0.137

 Teratoma

1

1

1.000

 Uterine fibroids

25

35

0.057

 Hysterectomy

9

17

0.052

 Uterine polyps

2

3

0.889

 Cervical cyst

2

0

0.501

 Endometrial hyperplasia

15

22

0.110

 Osteoporosis

4

2

0.796

 Fatty liver

25

20

0.728

 Hemangiomas

4

3

1.000

 Hepatic cyst

8

5

0.536

 Cholecystic polips

3

4

0.869

 Transaminase step-up

2

7

0.426

 Splenic hemangioma

0

1

0.469

 Cataracts

0

1

0.469