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Table 2 Associations between NOXA and MCL1 genotypes and SCCHN risk

From: Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck

Gene Varianta Control Overall (n = 372) Oropharynx (n = 184) Non-oropharynx (n = 188)
n = 315 (%) Patients (%) ORb (95%CI) Patients (%) ORb (95%CI) Patients (%) ORb (95%CI)
NOXA rs9957673        
 CC 216 (68.6) 246 (66.1) 1.0 118 (64.1) 1.0 128 (68.1) 1.0
 CT 95 (30.2) 115 (30.9) 1.0 (0.7-1.4) 60 (32.6) 1.1 (0.7-1.7) 55 (29.3) 1.1 (0.9-1.6)
 TT 4 (1.3) 11 (3.0) 2.3 (0.7-7.4) 6 (3.3) 1.9 (0.4-8.1) 5 (2.7) 2.0 (0.5-8.3)
    P trend =0.300   P trend = 0.180   P trend = 0.689
CT + TT 99 (31.4) 126 (33.9) 1.1 (0.8-1.5) 66 (35.9) 1.1 (0.7-1.7) 60 (31.9) 1.1 (0.7-1.6)
NOXA rs4558496        
 TT 216 (68.6) 253 (69.1) 1.0 121 (65.8) 1.0 136 (72.3) 1.0
 TG 85 (27.5) 107 (29.3) 1.0 (0.7-1.5) 61 (33.2) 1.23 (0.8-1.9) 48 (25.5) 0.9 (0.6-1.3)
 GG 14 (4.3) 6 (1.6) 0.4 (0.2-1.1) 2 (1.1) 0.34 (0.1-1.6) 4 (2.1) 0.4 (0.1-1.4)
    P trend =0.411   P trend = 0.913   P trend = 0.224
 TG + GG 99 (31.4) 115 (30.9) 1.0 (0.7-1.3) 63 (34.3) 1.1 (0.7-1.7) 52 (27.7) 0.8 (0.5-1.2)
MCL1 rs9803935        
 GG 95 (30.2) 127 (34.1) 1.0 65 (35.3) 1.0 62 (33.0) 1.0
 GT 157 (59.8) 169 (45.4) 0.8 (0.6-1.2) 77 (41.9) 0.8 (0.5-1.3) 92 (48.9) 0.9 (0.6-1.4)
 TT 63 (20.0) 76 (20.4) 0.9 (0.6-1.5) 42 (22.8) 1.1 (0.6-1.8) 34 (18.1) 0.9 (0.6-1.6)
    P trend =0.516   P trend = 0.726   P trend = 0.463
 GG + GT 252 (80.0) 296 (79.6) 1.0 142 (77.2) 1.0 154 (81.9) 1.0
 TT 63 (20.0) 76 (20.4) 1.0 (0.7-1.5) 42 (22.8) 1.2 (0.7-1.9) 34 (18.1) 1.0 (0.6-1.6)
MCL1 rs3738485        
 GG 93 (29.5) 128 (34.4) 1.0 65 (35.3) 1.0 63 (33.5) 1.0
 GC 155 (49.2) 168 (45.2) 0.8 (0.6-1.2) 77 (41.9) 0.8 (0.5-1.3) 91 (47.4) 0.9 (0.6-1.3)
 CC 67 (21.3) 76 (20.4) 0.9 (0.6-1.3) 42 (22.8) 1.0 (0.6-1.7) 34 (18.1) 0.9 (0.5-1.5)
    P trend =0.298   P trend = 0.528   P trend = 0.271
 GG + GC 248 (78.7) 296 (79.6) 1.0 142 (77.2) 1.0 154 (81.9) 1.0
 CC 67 (21.3) 76 (20.4) 1.0 (0.7-1.4) 42 (22.8) 1.1 (0.7-1.8) 34 (18.1) 0.9 (0.6-1.5)
  1. a The observed genotype frequencies among the controls were in agreement with Hardy-Weinberg equilibrium (P=0.069 for rs9957673, P=0.139 for rs4558496, P=0.898 for rs9803935, P=0.871 for rs3738485).
  2. b ORs were adjusted for age, sex, smoking, drinking, and HPV16 serology.