Clinical features and outcome of multiple primary malignancies involving hepatocellular carcinoma: A long-term follow-up study

Table 4 Multivariate analysis of prognostic factors in term of overall survival and HCC-specific survival

Characteristic	HCC-specific overall survival		Overall survival
Characteristic	Pvalue	HR (95.0% CI)	Pvalue	HR (95.0% CI)
AFP level	0.610	1.257 (0.522-3.030)	-	-
GGT level	0.449	1.485 (0.534-4.130)	-	-
Tumor number	0.174	2.151 (0.713-6.491)	-	-
Vascular invasion	0.148	2.550 (0.717-9.064)	-	-
TNM stage	0.250	2.016 (0.611-6.656)	-	-
Treatment for HCC	0.001	1.893 (1.297-2.764)	-	-
Time of appearance	-	-	0.535	1.329 (0.542-3.261)
Treatment for EHPM	-	-	<0.001	2.758 (1.581-4.811)

HCC: hepatocellular carcinoma, AFP: α-fetoprotein, GGT: gamma-glutamyltransferase, TNM: tumor-node-metastasis, EHPM: extrahepatic primary malignancy, HR: Hazard ratio, CI: confidence interval.

ISSN: 1471-2407