Figure 3

Immunohistochemical detection of HOXA1 in healthy oral mucosa and OSCC. Representative samples of healthy oral mucosa (A) and OSCC (B) of this study. In the healthy mucosa, HOXA1 was clearly limited to the nucleus of the epithelial cells located in the basal and suprabasal layers, whereas in the OSCCs, HOXA1-positive cells were broadly observed in the tumor (Original magnification x200). (C) The percentage of HOXA1-positive cells was significantly higher in OSCCs than in healthy oral mucosas (p < 0.001).