Parameters | CSCs | SAR-OS | MNNG/HOS |
|---|
LD50 (Gy) | 7.96 ± 3.00* | 3.12 ± 1.38 | 3.36 ± 0.55 |
α (Gy-1) | 0.06411 | 0.10526 | 0.05421 |
β (Gy-2) | 0.00353 | 0.03482 | 0.04323 |
α/β (Gy) | 18.16* | 3.02 | 1.25 |
R2
| 0.867 (n = 5) | 0.999 (n = 3) | 0.995 (n = 3) |
- Survival parameters were obtained from linear-quadratic model fitting of cell survival curves. The LD50 values correspond to the mean ± standard deviation of the indicated independent experiments, performed in triplicate. *p < 0.05 compared to SAR-OS and MNNG/HOS cells Abbreviations: LD50 - median lethal dose, α - probability of occurrence of a double-strand break induced by one ionizing particle, β - probability of two single-strand breaks combine and form a double-strand break, α/β - dose corresponding to the probability of occurrence of a double-strand break and the combination of two single-strand breaks be the same, R2 - Adjusted R-squared.
