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Table 3 IC50 values of chemotherapeutic drugs in CSCs, SAR-OS and MNNG/HOS cells

From: Therapeutic implications of an enriched cancer stem-like cell population in a human osteosarcoma cell line

 

IC50 (μM)

  
 

DOX

CIS

MTX

CSCs

0.80 ± 0.22*

14.71 ± 1.68*

0.050 ± 0.020*

SAR-OS

0.26 ± 0.04

7.96 ± 2.88

0.006 ± 0.001

MNNG/HOS

0.30 ± 0.07

6.61 ± 1.24

0.006 ± 0.001

  1. Results are expressed as the mean ± standard deviation of five independent experiments performed in duplicate. *p < 0.05 compared to SAR-OS and MNNG/HOS cells Abbreviations: IC50, half maximal inhibitory concentration; DOX, doxorubicin; CIS, cisplatin; MTX, methotrexate. Cells were incubated with increasing concentrations of DOX (0-60 μM), CIS (0-80 μM) and MTX (0-1000 μM) during 48 hours. The cytotoxicity was evaluated using the MTT colorimetric assay and the IC50 were obtained from sigmoidal fitting of cell survival curves.
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BMC Cancer

ISSN: 1471-2407

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