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Table 2 Patients and tumor characteristics in dependence of the intratumoral OCT1 mRNA expression

From: Downregulation of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) in human hepatocellular carcinoma and their prognostic significance

Characteristics OCT1 (SLC22A1)
Low expression
(< Median)
OCT1 (SLC22A1)
High expression
(≥ Median)
P-value
N 27 26  
Median follow-up in days (range) 434 (22-1538) 425 (109-1645) n.s. (0.20)
Male/female (n) 23/4 23/3 n.s. (1.00)
Median age in years (range) 69 (35-86) 67 (47-93) n.s. (0.35)
1-3 nodules/multiple nodules (specimen) 18/9 18/8 n.s. (1.00)
Tumor diameter < 3 cm/> 3 cm 5/22 14/12 0.010
Median tumor diameter in cm (range) 6.0 (1.5-30) 2.8 (0.1-20) 0.035
T classification: T1/T2/T3 (specimen) 8/7/12 10/13/3 0.025
Grading: G1/G2/G3/Gx 1/17/9/0 10/14/1/1 0.001
AFP > 100/< 100 * 9/16 2/24 0.019
Angioinvasion yes/no # 7/16 4/22 n.s. (0.31)
Child A/B/C/no cirrhosis 10/1/1/15 9/3/6/8 n.s. (0.08)
Underlying disease (HCV/HBV/alcoholic/others/unknown) 4/2/1/10/10 6/7/3/5/5 n.s. (0.11)
SLC22A3 mRNA expression
ratio HCC/TST (range)
0.21
(0.001-3.07)
0.86
(0.33-3.12)
0.008
Pretreatment with chemoembolization (yes/no) 2/25 18/8 < 0.001
Liver transplantation/resection 4/23 16/10 0.001
  1. Median: 0.112 * 2 unknown # 4 unknown
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