Figure 2
Prognostic relevance of peritumoral vascular invasion and membranous NHERF1 in invasive breast cancer. (A) Subgroup analysis revealed that the presence of PVI and the loss of membranous NHERF1 expression were adverse prognostic factors for grade 2 tumors (by Fisher's exact test). (B) The distribution analysis in the three distinct histological groups showed the PVI+/membranous NHERF1- expression phenotype significantly associated both to grade 2 and to grade 3 tumors (by χ 2 test). (C) The PVI+/membranous NHERF1- expression immunophenotype predicted poor prognosis in the whole cohort (by Fisher's exact test). (D) The PVI+/membranous NHERF1- expression immunophenotype correlated significantly with poor clinical outcome also in the subgroup of grade 2 familial tumors (by Fisher's exact test). Abbreviations: NPI = Nottingham Prognostic Index; PVI = peritumoral vascular invasion; neg = negative; pos = positive.