Skip to main content

Table 1 The common enhancer genes that potentiated the effect of topotecan from three screens

From: Synthetic Lethal Screen Identifies NF-κB as a Target for Combination Therapy with Topotecan for patients with Neuroblastoma

Genes that enhance the effect of topotecan-induced cell death
BIRC4 *, ** BOK * BBC3 CNTF ICEBERG PDCD2 TNFAIP1
CTSD *, ** CDKN2A * BCL11B DAP IGF1 PIK3C2G TNFAIP2
NFKB1 *, ** CDKN2D * BCL2A1 DNASE1 IL10RB PRDX5 TNFSF12
NOS2A *, ** F2R * BIRC3 DOCK1 IL1B PRF1 TNFSF5
RIPK1 *, ** MCL1 * BNIP3 DUSP7 LTB PTGS1 TP53
TGFB1 *, ** MMP9 * CARD10 ERCC6 MAP2K6 RAD23B TRAF1
TNFRSF10A *, ** STK3 * CARD14 FAF1 MAP3K14 RB1 TRAF6
TNFRSF25 *, ** TNFRSF10D * CASP9 GPX1 MYB SFRP5 WDR3
TNFRSF8 *, ** TP53BP2 * CLU HSPE1 NOS3 TIA1 YWHAZ
  1. Footnote: *genes present in the second screen (18); ** genes in all three screens (9)