Synthetic Lethal Screen Identifies NF-κB as a Target for Combination Therapy with Topotecan for patients with Neuroblastoma

Table 1 The common enhancer genes that potentiated the effect of topotecan from three screens

Genes that enhance the effect of topotecan-induced cell death
BIRC4 , *	BOK *	BBC3	CNTF	ICEBERG	PDCD2	TNFAIP1
CTSD , *	CDKN2A *	BCL11B	DAP	IGF1	PIK3C2G	TNFAIP2
NFKB1 , *	CDKN2D *	BCL2A1	DNASE1	IL10RB	PRDX5	TNFSF12
NOS2A , *	F2R *	BIRC3	DOCK1	IL1B	PRF1	TNFSF5
RIPK1 , *	MCL1 *	BNIP3	DUSP7	LTB	PTGS1	TP53
TGFB1 , *	MMP9 *	CARD10	ERCC6	MAP2K6	RAD23B	TRAF1
TNFRSF10A , *	STK3 *	CARD14	FAF1	MAP3K14	RB1	TRAF6
TNFRSF25 , *	TNFRSF10D *	CASP9	GPX1	MYB	SFRP5	WDR3
TNFRSF8 , *	TP53BP2 *	CLU	HSPE1	NOS3	TIA1	YWHAZ

Footnote: *genes present in the second screen (18); ** genes in all three screens (9)

ISSN: 1471-2407