Figure 1

Resveratrol blocks the cytotoxic effects of MG132 in K562 cells. A-B, Cell viability of K562 cells was determined using MTT assay after treatment with various concentrations of resveratrol (A) and MG132 (B) for 24 h, respectively. C, The percentage of viable cells was determined using MTT assay after treatment with 5 μM MG132 and various concentrations of resveratrol for 24 h. D, Cells were treated with 5 μM MG132 and various concentration of resveratrol for 24 h, apoptotic cells were analyzed. A-D, The results are presented as mean of three independent experiments performed in triplicate, and error bars represent standard deviation. E, K562 cells were treated with 5 μM MG132 and various concentration of resveratrol for 24 h, and Western blot analysis was performed. Representative blot from three independent experiments with similar results was shown. *, P < 0.05; **, P < 0.01.