Diet folate, DNA methylation and genetic polymorphisms of MTHFRC677T in association with the prognosis of esophageal squamous cell carcinoma

Table 2 Association between clinical characteristics and the prognosis of ESCC

Characteristics	Total patients	Death, N(%)	HR(95% CI)^†	P
Site
Upper	23	13(56.52)	1
Middle	64	30(46.88)	0.80(0.42-1.54)	0.507
Low	33	15(45.45)	0.74(0.35-1.55)	0.424
TNM stage
T
1	21	5(23.81)	1
2	44	15(34.09)	1.52(0.55-4.20)	0.414
3	47	31(65.96)	3.80(1.47-9.79)	0.006
4	8	7(87.50)	7.65(2.40-24.32)	0.001
P for trend				< 0.001
N
0	62	18(29.03)	1
1	58	40(68.97)	3.54(2.02-6.19)	< 0.001
M
0	119	58(48.74)	1
1	1	0(0)	-	-
Clinical stage
1/2	61	20(32.79)	1
3/4	59	38(64.41)	2.83(1.64-4.87)	< 0.001
Chemo-therapy
No	114	57(50.00)	1
Yes	6	1(16.67)	0.25(0.03-1.79)	0.167
Radio-therapy
No	91	41(45.05)	1
Yes	28	17(60.71)	1.45(0.83-2.56)	0.195

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