Figure 4
From: Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells
DNA methylation profile of PXR as detected by direct sequencing. Methylation status of the PXR gene in the 6 colon cancer cell lines and a cancerous tissue sample (255C) and its paired adjacent normal tissue sample (255N) detected by bisulfite direct sequencing. Open and closed circles represent unmethylated and fully methylated CpG sites, respectively. Half-closed circles represent partially methylated CpG sites. The methylation status of the CpG island (around exon 3) and CpG-rich promoter sequence (segments 1, 2, 3 and 4) are shown in the upper and lower panels, respectively.