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Table 5 Worst NCI-CTC grade of toxicity by patient, in the whole group of patients

From: Effects on quality of life of weekly docetaxel-based chemotherapy in patients with locally advanced or metastatic breast cancer: results of a single-centre randomized phase 3 trial

 

3-weekly, n (%)

Weekly, n (%)

Grade

0

1

2

3

4

5

0

1

2

3

4

5

Allergy

68

(98,6)

 

-

1

(1,4)

-

 

-

  

-

65

(98,5)

 

-

1

(1,5)

 

-

 

-

 

-

Anaemia

48

(69,6)

13

(18,8)

7

(10,1)

-

 

1

(1,4)

 

-

49

(74,2)

8

(12,1)

7

(10,6)

2

(3,0)

 

-

 

-

Neutropenia

21

(30,4)

 

-

3

(4,3)

19

(27,5)

26

(37,7)

 

-

36

(54,5)

10

(15,2)

9

(13,6)

7

(10,6)

4

(6,1)

 

-

Thrombocytopenia

66

(95,7)

 

-

2

(2,9)

 

-

1

(1,4)

 

-

64

(97,0)

1

(1,5)

 

-

1

(1,5)

 

-

  

Febrile Neutropenia

67

(97,1)

    

1

(1,4)

1

(1,4)

 

-

66

(100,0)

     

-

 

-

 

-

Neutropenic infection

59

(85,5)

4

(5,8)

5

(7,2)

 

-

 

-

1

(1,4)

61

(92,4)

1

(1,5)

4

(6,1)

 

-

 

-

 

-

Bleeding

66

(95,7)

2

(2,9)

 

-

 

-

 

-

1

(1,4)

64

(97,0)

1

(1,5)

 

-

1

(1,5)

 

-

 

-

Cardiac

61

(88,4)

6

(8,7)

1

(1,4)

1

(1,4)

 

-

 

-

59

(89,4)

4

(6,1)

2

(3,0)

1

(1,5)

 

-

 

-

Fatigue

43

(62,3)

16

(23,2)

10

(14,5)

 

-

 

-

 

-

41

(62,1)

11

(16,7)

13

(19,7)

1

(1,5)

 

-

 

-

Fever

60

(87,0)

4

(5,8)

5

(7,2)

 

-

 

-

 

-

62

(93,9)

2

(3,0)

1

(1,5)

1

(1,5)

 

-

 

-

Weight loss

69

(100,0)

 

-

 

-

 

-

 

-

 

-

64

(97,0)

1

(1,5)

1

(1,5)

 

-

 

-

 

-

Hair loss

24

(34,8)

1

(1,4)

44

(63,8)

      

33

(50,0)

8

(12,1)

25

(37,9)

      

Cutaneous

60

(87,0)

3

(4,3)

4

(5,8)

1

(1,4)

1

(1,4)

  

51

(77,3)

8

(12,1)

6

(9,1)

1

(1,5)

 

-

  

Conjunctivitis

66

(95,7)

1

(1,4)

2

(2,9)

 

-

 

-

 

-

61

(92,4)

3

(4,5)

2

(3,0)

 

-

 

-

 

-

Anorexia

67

(97,1)

2

(2,9)

 

-

 

-

 

-

  

66

(100,0)

 

-

 

-

 

-

 

-

  

Constipation

63

(91,3)

4

(5,8)

2

(2,9)

 

-

 

-

  

63

(95,5)

2

(3,0)

1

(1,5)

 

-

 

-

  

Diarrhoea

53

(76,8)

9

(13,0)

6

(8,7)

1

(1,4)

 

-

 

-

56

(84,8)

6

(9,1)

4

(6,1)

 

-

 

-

 

-

Dysgeusia

67

(97,1)

2

(2,9)

 

-

 

-

    

63

(95,5)

3

(4,5)

 

-

 

-

    

Nausea

26

(37,7)

25

(36,2)

17

(24,6)

1

(1,4)

 

-

  

31

(47,0)

26

(39,4)

8

(12,1)

1

(1,5)

 

-

  

Vomiting

46

(66,7)

14

(20,3)

7

(10,1)

1

(1,4)

1

(1,4)

 

-

46

(69,7)

14

(21,2)

4

(6,1)

2

(3,0)

 

-

 

-

Stomatitis

39

(56,5)

18

(26,1)

8

(11,6)

2

(2,9)

2

(2,9)

 

-

44

(66,7)

17

(25,8)

4

(6,1)

1

(1,5)

 

-

 

-

Abdominal pain

58

(84,1)

5

(7,2)

3

(4,3)

3

(4,3)

 

-

 

-

60

(90,9)

4

(6,1)

2

(3,0)

 

-

 

-

 

-

Skeletal pain

64

(92,8)

1

(1,4)

4

(5,8)

 

-

 

-

 

-

66

(100,0)

 

-

 

-

 

-

 

-

 

-

Diabetes

69

(100,0)

 

-

 

-

 

-

 

-

 

-

63

(95,5)

 

-

1

(1,5)

1

(1,5)

1

(1,5)

 

-

Hepatic

64

(92,8)

4

(5,8)

1

(1,4)

 

-

 

-

 

-

57

(86,4)

8

(12,1)

1

(1,5)

 

-

 

-

 

-

Neurologic

62

(89,9)

6

(8,7)

 

-

1

(1,4)

 

-

 

-

59

(89,4)

5

(7,6)

 

-

1

(1,5)

1

(1,5)

-

 

Pulmonary

69

(100,0)

 

-

 

-

 

-

 

-

 

-

64

(97,0)

2

(3,0)

 

-

 

-

 

-

-