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Table 5 Worst NCI-CTC grade of toxicity by patient, in the whole group of patients

From: Effects on quality of life of weekly docetaxel-based chemotherapy in patients with locally advanced or metastatic breast cancer: results of a single-centre randomized phase 3 trial

  3-weekly, n (%) Weekly, n (%)
Grade 0 1 2 3 4 5 0 1 2 3 4 5
Allergy 68 (98,6)   - 1 (1,4) -   -    - 65 (98,5)   - 1 (1,5)   -   -   -
Anaemia 48 (69,6) 13 (18,8) 7 (10,1) -   1 (1,4)   - 49 (74,2) 8 (12,1) 7 (10,6) 2 (3,0)   -   -
Neutropenia 21 (30,4)   - 3 (4,3) 19 (27,5) 26 (37,7)   - 36 (54,5) 10 (15,2) 9 (13,6) 7 (10,6) 4 (6,1)   -
Thrombocytopenia 66 (95,7)   - 2 (2,9)   - 1 (1,4)   - 64 (97,0) 1 (1,5)   - 1 (1,5)   -   
Febrile Neutropenia 67 (97,1)      1 (1,4) 1 (1,4)   - 66 (100,0)       -   -   -
Neutropenic infection 59 (85,5) 4 (5,8) 5 (7,2)   -   - 1 (1,4) 61 (92,4) 1 (1,5) 4 (6,1)   -   -   -
Bleeding 66 (95,7) 2 (2,9)   -   -   - 1 (1,4) 64 (97,0) 1 (1,5)   - 1 (1,5)   -   -
Cardiac 61 (88,4) 6 (8,7) 1 (1,4) 1 (1,4)   -   - 59 (89,4) 4 (6,1) 2 (3,0) 1 (1,5)   -   -
Fatigue 43 (62,3) 16 (23,2) 10 (14,5)   -   -   - 41 (62,1) 11 (16,7) 13 (19,7) 1 (1,5)   -   -
Fever 60 (87,0) 4 (5,8) 5 (7,2)   -   -   - 62 (93,9) 2 (3,0) 1 (1,5) 1 (1,5)   -   -
Weight loss 69 (100,0)   -   -   -   -   - 64 (97,0) 1 (1,5) 1 (1,5)   -   -   -
Hair loss 24 (34,8) 1 (1,4) 44 (63,8)        33 (50,0) 8 (12,1) 25 (37,9)       
Cutaneous 60 (87,0) 3 (4,3) 4 (5,8) 1 (1,4) 1 (1,4)    51 (77,3) 8 (12,1) 6 (9,1) 1 (1,5)   -   
Conjunctivitis 66 (95,7) 1 (1,4) 2 (2,9)   -   -   - 61 (92,4) 3 (4,5) 2 (3,0)   -   -   -
Anorexia 67 (97,1) 2 (2,9)   -   -   -    66 (100,0)   -   -   -   -   
Constipation 63 (91,3) 4 (5,8) 2 (2,9)   -   -    63 (95,5) 2 (3,0) 1 (1,5)   -   -   
Diarrhoea 53 (76,8) 9 (13,0) 6 (8,7) 1 (1,4)   -   - 56 (84,8) 6 (9,1) 4 (6,1)   -   -   -
Dysgeusia 67 (97,1) 2 (2,9)   -   -      63 (95,5) 3 (4,5)   -   -     
Nausea 26 (37,7) 25 (36,2) 17 (24,6) 1 (1,4)   -    31 (47,0) 26 (39,4) 8 (12,1) 1 (1,5)   -   
Vomiting 46 (66,7) 14 (20,3) 7 (10,1) 1 (1,4) 1 (1,4)   - 46 (69,7) 14 (21,2) 4 (6,1) 2 (3,0)   -   -
Stomatitis 39 (56,5) 18 (26,1) 8 (11,6) 2 (2,9) 2 (2,9)   - 44 (66,7) 17 (25,8) 4 (6,1) 1 (1,5)   -   -
Abdominal pain 58 (84,1) 5 (7,2) 3 (4,3) 3 (4,3)   -   - 60 (90,9) 4 (6,1) 2 (3,0)   -   -   -
Skeletal pain 64 (92,8) 1 (1,4) 4 (5,8)   -   -   - 66 (100,0)   -   -   -   -   -
Diabetes 69 (100,0)   -   -   -   -   - 63 (95,5)   - 1 (1,5) 1 (1,5) 1 (1,5)   -
Hepatic 64 (92,8) 4 (5,8) 1 (1,4)   -   -   - 57 (86,4) 8 (12,1) 1 (1,5)   -   -   -
Neurologic 62 (89,9) 6 (8,7)   - 1 (1,4)   -   - 59 (89,4) 5 (7,6)   - 1 (1,5) 1 (1,5) -  
Pulmonary 69 (100,0)   -   -   -   -   - 64 (97,0) 2 (3,0)   -   -   - -