Figure 5
Effect of c-MYC expression on the apoptotic activity of DAOY MB cells after exposure to DNA-damaging agents. IR (A), cisplatin (B), etoposide (C), and doxorubicin (D) enhance the induction of apoptotic cell death in c-MYC over-expressing DAOY cells, as determined by Cell Death ELISA assay at the different time points indicated. Values represent the mean absorbance of cytoplasmic histone-associated-DNA fragments ± standard deviation (n = 3). Student's t-test compared DAOY M2/treated cells vs. DAOY V11/treated cells (***: P < 0.001, **: P < 0.01,*: P < 0.05).