Identification of epigenetically regulated genes that predict patient outcome in neuroblastoma

BMC Cancer

Table 3 Methylation Δbeta values (methylation frequencies) between various tumor characteristics.

Gene	CpG site	INRG (M/L)	1p-del^a	MNA^a	11q-del^a	17q-gain^a	>18 m
SCNN1A	cg18738906	0.33***	0.15	0.21**	0.25***	0.34***	0.15*
	cg26215727	0.15**	0.04	0.13*	0.17**	0.20***	0.09
PRKCDBP	cg05628549	0.09	-0.06	0.12	0.08	0.09	-0.10
	cg16245261	0.17*	0.00	0.27***	0.15	0.19*	0.01
	cg18392783	0.12	-0.06	0.18**	0.10	0.12	-0.02
	cg18959478	0.12	-0.06	0.16*	0.10	0.11	-0.04
KRT19	cg11462865	0.14	-0.01	0.19*	0.10	0.12	0.22**
	cg16585619	0.01	-0.05*	0.07***	0.04*	0.03	0.01
TGFBI	cg00386408	0.05	-0.04	0.11	0.10	0.07	0.14*
	cg21034676	0.04	-0.04	0.13	0.06	0.05	0.12
POU2F2	cg21608489	-0.08	-0.05	-0.08	-0.01	-0.04	-0.08
	cg22054191	0.03	-0.03	-0.01	0.04	0.02	0.04
DUSP23	cg10663017	0.06	-0.10	0.27***	0.21***	0.16**	0.07
	cg11104347	0.05	-0.13*	0.29***	0.16**	0.13**	0.08
DHRS3	cg01346152	-0.13	-0.03	-0.20**	-0.03	-0.08	-0.10
	cg09229231	0.004*	0.00	0.00	0.00	0.00	0.00
COL1A2	cg18511007	0.07	0.00	0.05	0.07	-0.01	0.18**
	cg25300386	0.02	-0.04	-0.02	0.02	-0.09	0.15*

M, metastatic; L, localized; 1p-del, 1p-deletion; MNA, MYCN amplification; 11q-del, 11q-deletion; m, months; ^apresence of chromosomal aberration tested against absence; *p ≤ 0.05; **p < 0.01; ***p < 0.001

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