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Table 4 Genes regulated by TEL-JAK2 at steady state.

From: Tyrosine kinase chromosomal translocations mediate distinct and overlapping gene regulation events

Microarray Analysis
Genes Regulated by TEL-JAK2
  Fold-Change Gene Name
Induced Genes 3.90 0-6-methylguanine-DNA methyltransferase (Mgmt)
  3.20 Serum deprivation response (Sdpr)
  3.18 Growth arrest specific 5 (Gas5)
  3.13 Immediate early response 2 (Ier2)
  2.74 Cbp/p300 interacting transactivator 2 (Cited2)
  2.69 E2f transcription factor 6 (E2f6)
  2.38 Pannexin 1 (Panx1)
  2.17 Myosin VIIa (Myo7a)
  2.12 Tnf receptor-associate factor 5 (Traf5)
  2.12 Cyclin-dependent kinase inhibitor 2a (Cdkn2a)
  2.00 Rab33b, member of Ras oncogene family (Rab33b)
Suppressed Genes 6.81 Chemokine (C-C) receptor 1 (Ccr1)
  3.30 Apoptosis inhibitory protein 5 (Api5)
  2.98 Bcl2 adenovirus E1b 19 kDa interacting protein 3-like (Bnip3)
  2.85 Runt-related transcription factor 1 (Runx1)
  2.68 Lim only 4 (Lmo4)
  2.61 Chemokine (CXC motif) ligand 13 (Cxcl13)
  2.47 Axin1 (Axin1)
  2.17 Rho family GTPase RhoA (RhoA)
  2.12 Chemokine (C-C motif) receptor 1 (Ccr1)
  1. Ba/F3 cells were washed and incubated in IL-3-depleted media for 5 h and total RNA was collected as reference RNA. Ba/F3 TEL-JAK2 cells were washed three times and incubated in IL-3-depleted media for 1 week and total RNA was collected. Microarray analysis was performed and changes in the gene expression between the reference RNA and the RNA collected from Ba/F3 TEL-JAK2 cells were calculated. Genes that are induced or suppressed by two fold or greater were identified.