Tyrosine kinase chromosomal translocations mediate distinct and overlapping gene regulation events

BMC Cancer

Table 4 Genes regulated by TEL-JAK2 at steady state.

Microarray Analysis
Genes Regulated by TEL-JAK2
	Fold-Change	Gene Name
Induced Genes	3.90	0-6-methylguanine-DNA methyltransferase (Mgmt)
	3.20	Serum deprivation response (Sdpr)
	3.18	Growth arrest specific 5 (Gas5)
	3.13	Immediate early response 2 (Ier2)
	2.74	Cbp/p300 interacting transactivator 2 (Cited2)
	2.69	E2f transcription factor 6 (E2f6)
	2.38	Pannexin 1 (Panx1)
	2.17	Myosin VIIa (Myo7a)
	2.12	Tnf receptor-associate factor 5 (Traf5)
	2.12	Cyclin-dependent kinase inhibitor 2a (Cdkn2a)
	2.00	Rab33b, member of Ras oncogene family (Rab33b)
Suppressed Genes	6.81	Chemokine (C-C) receptor 1 (Ccr1)
	3.30	Apoptosis inhibitory protein 5 (Api5)
	2.98	Bcl2 adenovirus E1b 19 kDa interacting protein 3-like (Bnip3)
	2.85	Runt-related transcription factor 1 (Runx1)
	2.68	Lim only 4 (Lmo4)
	2.61	Chemokine (CXC motif) ligand 13 (Cxcl13)
	2.47	Axin1 (Axin1)
	2.17	Rho family GTPase RhoA (RhoA)
	2.12	Chemokine (C-C motif) receptor 1 (Ccr1)

Ba/F3 cells were washed and incubated in IL-3-depleted media for 5 h and total RNA was collected as reference RNA. Ba/F3 TEL-JAK2 cells were washed three times and incubated in IL-3-depleted media for 1 week and total RNA was collected. Microarray analysis was performed and changes in the gene expression between the reference RNA and the RNA collected from Ba/F3 TEL-JAK2 cells were calculated. Genes that are induced or suppressed by two fold or greater were identified.

ISSN: 1471-2407