Figure 5
From: Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma
Nuclear localization of YAP1 is frequently detectable in ccRCCs with SAV1 downregulation. Immunohistochemistry of ccRCC tissues using anti-SAV1 antibody and anti-YAP1 antibody (×400). Representative results are shown. YAP1 tends to be localized in the nucleus of tumor cells in cases showing downregulation of SAV1 (case #96), whereas it tends to be localized mainly in the cytoplasm of tumor cells without downregulation of SAV1 (case #84). The cytoplasm of endothelial cells is positively immunostained. No positive staining is detectable in both cases using normal mouse IgG as the primary antibody (IgG).