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Table 1 HSD17B1 transcript and protein levels in primary cancerous and histopathologically unchanged tissue samples from patient with CRC.

From: Decreased expression of 17β-hydroxysteroid dehydrogenase type 1 is associated with DNA hypermethylation in colorectal cancer located in the proximal colon

n = 52 Primary cancerous tissues Histopathologically unchanged tissues Pc
   Median (range) Mean (± SD) Median (range) Mean (± SD)  
Age (Years)       
<60 10 3.511 (2.109-3.868) a 3.282 ± 0.5921 a 3.415 (2.726-5.107)a 3.611 ± 0.6309 a 0.2450a
   2.634 (1.681-3.218)b 2.579 ± 0.5243b 2.620 (2.108-3.398)b 2.719 ± 0.4843b 0.5423b
>60 42 3.531 (2.071-5.227) a 3.569 ± 0.6649 a 3.692 (2.790-5.785)a 3.834 ± 0.6251a 0.1087a
   2.728 (1.728-4.023)b 2.720 ± 0.4702b 2.952 (1.364-3.472)b 2.835 ± 0.4913b 0.1121b
Gender       
Female 20 3.384 (2.109-4.455) a 3.371 ± 0.5676 a 3.449 (2.726-5.785)a 3.719 ± 0.7333a 0.2340 a
   2.793 (1.681-3.218)b 2.666 ± 0.4767b 2.811 (2.108-3.472)b 2.844 ± 0.4065b 0.2119b
Male 32 3.571 (2.071-4.653) a 3.557 ± 0.6523 a 3.857(2.790-5.259) a 3.890 ± 0.5855 a 0.0388 a
   2.702 (1.728-4.023)b 2.713 ± 0.4941b 2.962 (1.364-3.449)b 2.792 ± 0.5395b 0.2832b
CRC localization       
Proximal colon (cecum to transverse) 20 3.507(2.666-4.455) a 3.427 ± 0.4350 a 3.874 (3.050-5.785) a 4.057 ± 0.7488 a 0.0016 a
   2.793 (1.681-3.218)b 2.666 ± 0.4767b 2.811 (2.108-3.472)b 2.844 ± 0.4065b 0.0028b
Distal colon (splenic flexture to sigmoid) 12 3.214 (2.071-4.313) a 3.218 ± 0.7760 a 3.449 (2.726-4.587) a 3.630 ± 0.6372 a 0.1685 a
   2.798 (1.772-3.254)b 2.691 ± 0.4777b 2.860 (1.364-3.391)b 2.619 ± 0.6350b 0.7763b
Rectum 20 3.544 (2.523-4.653) a 3.657 ± 0.6011 a 3.564 (3.226-4.862) a 3.762 ± 0.500 a 0.8839 a
   2.951 (1.728-3.398)b 2.815 ± 0.4436b 2.988 (2.019-3.383)b 2.913 ± 0.3871b 0.5019b
Histologic grade       
G1 4 4.059 (2.362-4.402) a 3.721 ± 0.9467 a 4.431 (3.123-5.259) a 4.311 ± 0.9076 a 0.4026 a
   2.926 (2.586-3.040)b 2.870 ± 0.2060b 2.789 (2.026-3.147)b 2.688 ± 0.5370b 0.5506b
G2 35 3.379 (2.109-4.621) a 3.363 ± 0.5385 a 3.524 (2.726-5.785) a 3.681 ± 0.5619 a 0.0335 a
   2.647 (1.681-4.023)b 2.649 ± 0.4993b 2.933 (2.019-3.472)b 2.863 ± 0.4114b 0.0659b
G3 13 3.875 (2.071-4.839) a 3.807 ± 0.7092 a 4.043 (2.790-5.227) a 4.165 ± 0.7346 a 0.2587 a
   2.676 (1.845-3.431)b 2.670 ± 0.5098b 3.023 (1.364-3.449)b 2.763 ± 0.6858b 0.5114b
  1. The HSD17B1 transcript levelsa were standardized by the geometric mean of PBGD and hMRPL19 cDNA and expressed as decimal logarithm of multiples of these cDNA copies in calibrator. b The amount of western blot-detected proteins was presented as the decimal logarithm HSD17B1 to β-actin band optical density ratio. c Unpaired, two-tailed t-test or U-Mann-Whitney test.