|
n = 52
|
Primary cancerous tissues
|
Histopathologically unchanged tissues
|
Pc
|
|---|
| | |
Median (range)
|
Mean (± SD)
|
Median (range)
|
Mean (± SD)
| |
|---|
|
Age (Years)
| | | | | | |
|
<60
|
10
|
3.511 (2.109-3.868) a
|
3.282 ± 0.5921 a
|
3.415 (2.726-5.107)a
|
3.611 ± 0.6309 a
|
0.2450a
|
| | |
2.634 (1.681-3.218)b
|
2.579 ± 0.5243b
|
2.620 (2.108-3.398)b
|
2.719 ± 0.4843b
|
0.5423b
|
|
>60
|
42
|
3.531 (2.071-5.227) a
|
3.569 ± 0.6649 a
|
3.692 (2.790-5.785)a
|
3.834 ± 0.6251a
|
0.1087a
|
| | |
2.728 (1.728-4.023)b
|
2.720 ± 0.4702b
|
2.952 (1.364-3.472)b
|
2.835 ± 0.4913b
|
0.1121b
|
|
Gender
| | | | | | |
|
Female
|
20
|
3.384 (2.109-4.455) a
|
3.371 ± 0.5676 a
|
3.449 (2.726-5.785)a
|
3.719 ± 0.7333a
|
0.2340 a
|
| | |
2.793 (1.681-3.218)b
|
2.666 ± 0.4767b
|
2.811 (2.108-3.472)b
|
2.844 ± 0.4065b
|
0.2119b
|
|
Male
|
32
|
3.571 (2.071-4.653) a
|
3.557 ± 0.6523 a
|
3.857(2.790-5.259) a
|
3.890 ± 0.5855 a
|
0.0388 a
|
| | |
2.702 (1.728-4.023)b
|
2.713 ± 0.4941b
|
2.962 (1.364-3.449)b
|
2.792 ± 0.5395b
|
0.2832b
|
|
CRC localization
| | | | | | |
|
Proximal colon (cecum to transverse)
|
20
|
3.507(2.666-4.455) a
|
3.427 ± 0.4350 a
|
3.874 (3.050-5.785) a
|
4.057 ± 0.7488 a
|
0.0016 a
|
| | |
2.793 (1.681-3.218)b
|
2.666 ± 0.4767b
|
2.811 (2.108-3.472)b
|
2.844 ± 0.4065b
|
0.0028b
|
|
Distal colon (splenic flexture to sigmoid)
|
12
|
3.214 (2.071-4.313) a
|
3.218 ± 0.7760 a
|
3.449 (2.726-4.587) a
|
3.630 ± 0.6372 a
|
0.1685 a
|
| | |
2.798 (1.772-3.254)b
|
2.691 ± 0.4777b
|
2.860 (1.364-3.391)b
|
2.619 ± 0.6350b
|
0.7763b
|
|
Rectum
|
20
|
3.544 (2.523-4.653) a
|
3.657 ± 0.6011 a
|
3.564 (3.226-4.862) a
|
3.762 ± 0.500 a
|
0.8839 a
|
| | |
2.951 (1.728-3.398)b
|
2.815 ± 0.4436b
|
2.988 (2.019-3.383)b
|
2.913 ± 0.3871b
|
0.5019b
|
|
Histologic grade
| | | | | | |
|
G1
|
4
|
4.059 (2.362-4.402) a
|
3.721 ± 0.9467 a
|
4.431 (3.123-5.259) a
|
4.311 ± 0.9076 a
|
0.4026 a
|
| | |
2.926 (2.586-3.040)b
|
2.870 ± 0.2060b
|
2.789 (2.026-3.147)b
|
2.688 ± 0.5370b
|
0.5506b
|
|
G2
|
35
|
3.379 (2.109-4.621) a
|
3.363 ± 0.5385 a
|
3.524 (2.726-5.785) a
|
3.681 ± 0.5619 a
|
0.0335 a
|
| | |
2.647 (1.681-4.023)b
|
2.649 ± 0.4993b
|
2.933 (2.019-3.472)b
|
2.863 ± 0.4114b
|
0.0659b
|
|
G3
|
13
|
3.875 (2.071-4.839) a
|
3.807 ± 0.7092 a
|
4.043 (2.790-5.227) a
|
4.165 ± 0.7346 a
|
0.2587 a
|
| | |
2.676 (1.845-3.431)b
|
2.670 ± 0.5098b
|
3.023 (1.364-3.449)b
|
2.763 ± 0.6858b
|
0.5114b
|
- The HSD17B1 transcript levelsa were standardized by the geometric mean of PBGD and hMRPL19 cDNA and expressed as decimal logarithm of multiples of these cDNA copies in calibrator. b The amount of western blot-detected proteins was presented as the decimal logarithm HSD17B1 to β-actin band optical density ratio. c Unpaired, two-tailed t-test or U-Mann-Whitney test.
