n = 52

Primary cancerous tissues

Histopathologically unchanged tissues

P^{c}


 
Median (range)

Mean (± SD)

Median (range)

Mean (± SD)
 

Age (Years)
      
<60

10

3.511 (2.1093.868) ^{a}

3.282 ± 0.5921 ^{a}

3.415 (2.7265.107)^{a}

3.611 ± 0.6309 ^{a}

0.2450^{a}

 
2.634 (1.6813.218)^{b}

2.579 ± 0.5243^{b}

2.620 (2.1083.398)^{b}

2.719 ± 0.4843^{b}

0.5423^{b}

>60

42

3.531 (2.0715.227) ^{a}

3.569 ± 0.6649 ^{a}

3.692 (2.7905.785)^{a}

3.834 ± 0.6251^{a}

0.1087^{a}

 
2.728 (1.7284.023)^{b}

2.720 ± 0.4702^{b}

2.952 (1.3643.472)^{b}

2.835 ± 0.4913^{b}

0.1121^{b}

Gender
      
Female

20

3.384 (2.1094.455) ^{a}

3.371 ± 0.5676 ^{a}

3.449 (2.7265.785)^{a}

3.719 ± 0.7333^{a}

0.2340 ^{a}

 
2.793 (1.6813.218)^{b}

2.666 ± 0.4767^{b}

2.811 (2.1083.472)^{b}

2.844 ± 0.4065^{b}

0.2119^{b}

Male

32

3.571 (2.0714.653) ^{a}

3.557 ± 0.6523 ^{a}

3.857(2.7905.259) ^{a}

3.890 ± 0.5855 ^{a}

0.0388 ^{a}

 
2.702 (1.7284.023)^{b}

2.713 ± 0.4941^{b}

2.962 (1.3643.449)^{b}

2.792 ± 0.5395^{b}

0.2832^{b}

CRC localization
      
Proximal colon (cecum to transverse)

20

3.507(2.6664.455) ^{a}

3.427 ± 0.4350 ^{a}

3.874 (3.0505.785) ^{a}

4.057 ± 0.7488 ^{a}

0.0016 ^{a}

 
2.793 (1.6813.218)^{b}

2.666 ± 0.4767^{b}

2.811 (2.1083.472)^{b}

2.844 ± 0.4065^{b}

0.0028^{b}

Distal colon (splenic flexture to sigmoid)

12

3.214 (2.0714.313) ^{a}

3.218 ± 0.7760 ^{a}

3.449 (2.7264.587) ^{a}

3.630 ± 0.6372 ^{a}

0.1685 ^{a}

 
2.798 (1.7723.254)^{b}

2.691 ± 0.4777^{b}

2.860 (1.3643.391)^{b}

2.619 ± 0.6350^{b}

0.7763^{b}

Rectum

20

3.544 (2.5234.653) ^{a}

3.657 ± 0.6011 ^{a}

3.564 (3.2264.862) ^{a}

3.762 ± 0.500 ^{a}

0.8839 ^{a}

 
2.951 (1.7283.398)^{b}

2.815 ± 0.4436^{b}

2.988 (2.0193.383)^{b}

2.913 ± 0.3871^{b}

0.5019^{b}

Histologic grade
      
G1

4

4.059 (2.3624.402) ^{a}

3.721 ± 0.9467 ^{a}

4.431 (3.1235.259) ^{a}

4.311 ± 0.9076 ^{a}

0.4026 ^{a}

 
2.926 (2.5863.040)^{b}

2.870 ± 0.2060^{b}

2.789 (2.0263.147)^{b}

2.688 ± 0.5370^{b}

0.5506^{b}

G2

35

3.379 (2.1094.621) ^{a}

3.363 ± 0.5385 ^{a}

3.524 (2.7265.785) ^{a}

3.681 ± 0.5619 ^{a}

0.0335 ^{a}

 
2.647 (1.6814.023)^{b}

2.649 ± 0.4993^{b}

2.933 (2.0193.472)^{b}

2.863 ± 0.4114^{b}

0.0659^{b}

G3

13

3.875 (2.0714.839) ^{a}

3.807 ± 0.7092 ^{a}

4.043 (2.7905.227) ^{a}

4.165 ± 0.7346 ^{a}

0.2587 ^{a}

 
2.676 (1.8453.431)^{b}

2.670 ± 0.5098^{b}

3.023 (1.3643.449)^{b}

2.763 ± 0.6858^{b}

0.5114^{b}

 The HSD17B1 transcript levels^{a} were standardized by the geometric mean of PBGD and hMRPL19 cDNA and expressed as decimal logarithm of multiples of these cDNA copies in calibrator. ^{b} The amount of western blotdetected proteins was presented as the decimal logarithm HSD17B1 to βactin band optical density ratio. ^{c} Unpaired, twotailed ttest or UMannWhitney test.