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Table 1 Characteristics of populations and cancer types of the studies included in the meta-analysis

From: The association of APE1 −656T > G and 1349 T > G polymorphisms and cancer risk: a meta-analysis based on 37 case-control studies

Study

Country

Ethnicity

Cancer type

Sample size case/control

Source of controls

Genotyping method

Polymorphisms

Misra 2003 20

Finland

European

Lung cancer

310/302

Population

TaqMan

1349 T > G

Popanda 2004 21

Germany

European

Lung cancer

459/457

Hospital

Rapid capillary PCR

1349 T > G

Hao 2004 22

China

Asian

Oesophageal cancer

409/478

Population

PCR-RFLP

1349 T > G

Ito 2004 23

Japan

Asian

Lung cancer

178/449

Hospital

PCR-RFLP

1349 T > G

Shen 2005 24

China

Asian

Lung cancer

117/113

Population

TaqMan

1349 T > G

Moreno 2006 25

Spain

European

Colorectal cancer

359/312

Hospital

Arrayed primer extension

1349 T > G

Jiao 2006 26

USA

European

Pancreatic cancer

367/330

Hospital

Allele-specific PCR

1349 T > G

Terry 2006 27

USA

European

Bladder cancer

229/207

Hospital

MALDI-TOF

1349 T > G

Wu 2006 28

USA

European

Bladder cancer

596/590

Hospital

TaqMan

1349 T > G

Zhang 2006 29

USA

European

Breast cancer

1529/1207

Population

TaqMan

1349 T > G

Matullo 2006 30

Multi-country

European

Breast cancer

124/1094

Population

TaqMan

1349 T > G

   

Lung cancer

116/1094

Population

TaqMan

1349 T > G

   

Head and neck cancer

82/1094

Population

TaqMan

1349 T > G

   

Leukemia

169/1094

Population

TaqMan

1349 T > G

Chen 2006 31

USA

Mixed

Prostate cancer

351/329

Hospital

PCR-RFLP

1349 T > G

Li 2007 32

USA

European

Head and neck cancer

830/854

Hospital

PCR-RFLP

1349 T > G

Berndt 2007 14

USA

European

Colorectal cancer

767/773

Population

TaqMan

1349 T > G, −656 T > G

Figueroa 2007 15

Spain

European

Bladder cancer

1150/1149

Hospital

TaqMan

1349 T > G, −656 T > G

Andrew 2008 33

USA/Italy

European

Bladder cancer

911/1165

Population

SNP mass-tagging system

1349 T > G

Pardini 2008 34

Czech

European

Colorectal cancer

531/530

Hospital

TaqMan

1349 T > G

Mitra 2008 35

India

European

Bladder cancer

150/225

Population

PCR-RFLP

1349 T > G

Tse 2008 36

USA

European

Colorectal cancer

311/454

Hospital

TaqMan

1349 T > G

Huang 2008 37

China

Asian

Biliary tract cancer

409/783

Population

TaqMan

1349 T > G

Chiang 2008 38

China

Asian

Thyroid cancer

283/469

Hospital

TaqMan

1349 T > G

Smith 2008 39

USA

Asian

Breast cancer

372/480

Hospital

Arrayed primer extension

1349 T > G

Gangwar 2009 40

India

European

Bladder cancer

206/250

Hospital

TaqMan

1349 T > G

Agachan 2009 41

Turkey

European

Lung cancer

98/67

Hospital

PCR-RFLP

1349 T > G

Lo 2009 11

China

Asian

Lung cancer

729/722

Hospital

Arrayed primer extension

1349 T > G, −656 T > G

Lu 2009 10

China

Asian

Lung cancer

500/517

Population

Illumina

1349 T > G, −656 T > G

   

Lung cancer

572/547

Hospital

SNPscan

−656 T > G

Wang 2010 12

China

Asian

Bladder cancer

234/253

Hospital

PCR-RFLP

1349 T > G, -656 T > G

Deng 2010 42

China

Asian

Lung cancer

315/314

Population

RT-PCR

1349 T > G

Palli 2010 43

Italy

European

Gastric cancer

298/546

Population

TaqMan

1349 T > G

Jelonek 2010 44

Poland

European

Colorectal cancer

113/153

Hospital

PCR-RFLP

1349 T > G

   

Breast cancer

91/412

Hospital

PCR-RFLP

1349 T > G

Zhou 2011 13

China

Asian

Brain cancer

750/816

Hospital

MassARRAY

−656 T > G

Cao 2011 45

China

Asian

Renal cell carcinoma

612/632

Hospital

TaqMan

1349 T > G, -656 T > G

  1. RFLP, restriction fragment length polymorphism; PCR, polymerase chain reaction; MALDI-TOF, matrix assisted laser desorption/ionization time-of-flight; SNP, single nucleotide polymorphism; C, cytosine; T, thymine; PCR-CTPP, polymerase chain reaction with confronting two-pair primers.