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Table 1 Characteristics of populations and cancer types of the studies included in the meta-analysis

From: The association of APE1 −656T > G and 1349 T > G polymorphisms and cancer risk: a meta-analysis based on 37 case-control studies

Study Country Ethnicity Cancer type Sample size case/control Source of controls Genotyping method Polymorphisms
Misra 2003 20 Finland European Lung cancer 310/302 Population TaqMan 1349 T > G
Popanda 2004 21 Germany European Lung cancer 459/457 Hospital Rapid capillary PCR 1349 T > G
Hao 2004 22 China Asian Oesophageal cancer 409/478 Population PCR-RFLP 1349 T > G
Ito 2004 23 Japan Asian Lung cancer 178/449 Hospital PCR-RFLP 1349 T > G
Shen 2005 24 China Asian Lung cancer 117/113 Population TaqMan 1349 T > G
Moreno 2006 25 Spain European Colorectal cancer 359/312 Hospital Arrayed primer extension 1349 T > G
Jiao 2006 26 USA European Pancreatic cancer 367/330 Hospital Allele-specific PCR 1349 T > G
Terry 2006 27 USA European Bladder cancer 229/207 Hospital MALDI-TOF 1349 T > G
Wu 2006 28 USA European Bladder cancer 596/590 Hospital TaqMan 1349 T > G
Zhang 2006 29 USA European Breast cancer 1529/1207 Population TaqMan 1349 T > G
Matullo 2006 30 Multi-country European Breast cancer 124/1094 Population TaqMan 1349 T > G
    Lung cancer 116/1094 Population TaqMan 1349 T > G
    Head and neck cancer 82/1094 Population TaqMan 1349 T > G
    Leukemia 169/1094 Population TaqMan 1349 T > G
Chen 2006 31 USA Mixed Prostate cancer 351/329 Hospital PCR-RFLP 1349 T > G
Li 2007 32 USA European Head and neck cancer 830/854 Hospital PCR-RFLP 1349 T > G
Berndt 2007 14 USA European Colorectal cancer 767/773 Population TaqMan 1349 T > G, −656 T > G
Figueroa 2007 15 Spain European Bladder cancer 1150/1149 Hospital TaqMan 1349 T > G, −656 T > G
Andrew 2008 33 USA/Italy European Bladder cancer 911/1165 Population SNP mass-tagging system 1349 T > G
Pardini 2008 34 Czech European Colorectal cancer 531/530 Hospital TaqMan 1349 T > G
Mitra 2008 35 India European Bladder cancer 150/225 Population PCR-RFLP 1349 T > G
Tse 2008 36 USA European Colorectal cancer 311/454 Hospital TaqMan 1349 T > G
Huang 2008 37 China Asian Biliary tract cancer 409/783 Population TaqMan 1349 T > G
Chiang 2008 38 China Asian Thyroid cancer 283/469 Hospital TaqMan 1349 T > G
Smith 2008 39 USA Asian Breast cancer 372/480 Hospital Arrayed primer extension 1349 T > G
Gangwar 2009 40 India European Bladder cancer 206/250 Hospital TaqMan 1349 T > G
Agachan 2009 41 Turkey European Lung cancer 98/67 Hospital PCR-RFLP 1349 T > G
Lo 2009 11 China Asian Lung cancer 729/722 Hospital Arrayed primer extension 1349 T > G, −656 T > G
Lu 2009 10 China Asian Lung cancer 500/517 Population Illumina 1349 T > G, −656 T > G
    Lung cancer 572/547 Hospital SNPscan −656 T > G
Wang 2010 12 China Asian Bladder cancer 234/253 Hospital PCR-RFLP 1349 T > G, -656 T > G
Deng 2010 42 China Asian Lung cancer 315/314 Population RT-PCR 1349 T > G
Palli 2010 43 Italy European Gastric cancer 298/546 Population TaqMan 1349 T > G
Jelonek 2010 44 Poland European Colorectal cancer 113/153 Hospital PCR-RFLP 1349 T > G
    Breast cancer 91/412 Hospital PCR-RFLP 1349 T > G
Zhou 2011 13 China Asian Brain cancer 750/816 Hospital MassARRAY −656 T > G
Cao 2011 45 China Asian Renal cell carcinoma 612/632 Hospital TaqMan 1349 T > G, -656 T > G
  1. RFLP, restriction fragment length polymorphism; PCR, polymerase chain reaction; MALDI-TOF, matrix assisted laser desorption/ionization time-of-flight; SNP, single nucleotide polymorphism; C, cytosine; T, thymine; PCR-CTPP, polymerase chain reaction with confronting two-pair primers.