Figure 1From: Targeting hypoxic tumour cells to overcome metastasis Targeting tumour hypoxia to overcome metastasis. Functional inhibition of the HIF-1 transcription factor or hypoxia-inducible proteins, such as CAIX, LOX, or CXCR4, can affect multiple steps in the metastatic process. A range of hypoxia-activated cytotoxins are also available to directly target hypoxic cells in primary tumours and in distant tumour metastases.Back to article page