Breast cancer patients with lobular cancer more commonly have a father than a mother diagnosed with cancer

BMC Cancer

Table 2 Breast cancer subtype in relation to parental cancer diagnosis status

a)		Father with cancer, n = 297			Mother with cancer, n = 328
	n	OR	95% CI	p-value	OR	95% CI	p-value
Ductal	630	0.95	0.74-1.12	0.71	1.13	1.01-1.65	0.04
Lobular	137	1.76	1.17-2.63	0.006	1.03	0.66-1.60	0.90
Tubular	43	0.84	0.37-1.93	0.69	0.41	0.16-1.08	0.07
Medullary	26	0.39	0.09-1.65	0.20	0.44	0.13-1.55	0.20
Mucinous	25	0.90	0.30-2.65	0.85	0.91	0.32-2.62	0.87
b)		Father with cancer, n = 297			Mother with cancer, excluding breast cancer, n = 245
	n	OR	95% CI	p-value	OR	95% CI	p-value
Ductal	629	0.95	0.73-1.23	0.70	1.30	0.99-1.71	0.06
Lobular	137	1.77	1.18-2.65	0.006	0.84	0.51-1.41	0.52
Tubular	43	0.85	0.37-1.93	0.69	0.52	0.18-1.48	0.22
Medullary	26	0.39	0.09-1.65	0.20	0.78	0.23-2.63	0.69
Mucinous	25	0.92	0.31-2.72	0.88	0.26	0.03-1.91	0.18

Logistic regression models with histopathologic type of breast cancer as dependent variable related to having a father and/or a mother diagnosed with cancer. a, b) were both adjusted for age at diagnosis, breast cancer heredity, ever-use of HRT and number of children. N = 1661. b) was similar to a) but cases with a mother diagnosed with breast cancer were excluded from the analysis. N = 1661. There was no interaction between having a father and a mother diagnosed with cancer; β = 0.681, p-value = 0.428 (data not shown).

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