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Table 1 Using Independent HCC Studies to Validate HKU Gene Signature Identified at 0.0005 Level*

From: Clinicopathologic and gene expression parameters predict liver cancer prognosis

HKU Gene Signature in Normal Tissue
  Survival (1074 HKU Gene Signature)
  Overlapping Genes Enrichment p-value
Japanese Gene Signature 33 4.8E-13
Chinese-Belgium Gene Signature 41 1.1E-13
Asia HCC Metastases Gene Signature 31 1.0E-5
Singapore Gene Signature 5 1.2E-2
  Disease Free Survival (1195 HKU Gene Signature)
  Overlapping Genes Enrichment p-value
Japanese Gene Signature 34 1.9E-12
Chinese-Belgium Gene Signature 36 2.7E-9
Asia HCC Metastases Gene Signature 36 8.1E-7
Singapore Gene Signature 5 1.9E-2
HKU Gene Signature in Tumor Tissue
  Survival (660 HKU Gene Signature)
  Overlapping Genes Enrichment p-value
Japanese Gene Signature 5 0.36
Chinese-Belgium Gene Signature 22 4.6E-7
Asia HCC Metastases Gene Signature 6 0.13
Singapore Gene Signature 1 0.11
  Disease Free Survival (2169 HKU Gene Signature)
  Overlapping Genes Enrichment p-value
Japanese Gene Signature 6 0.12
Chinese-Belgium Gene Signature 28 1.4E-12
Asia HCC Metastases Gene Signature 20 1.6E-5
Singapore Gene Signature 1 0.27
  1. *Herein, we compared gene signatures obtained in following studies: HKU study (sample size N = 229 for adjacent normal tissues and N = 267 for tumor tissues), Japan study (175 gene signature based on sample size N = 82), Asia HCC Metastases study (307 gene signature based on sample size N = 115), China-Belgium study (247 gene signature based on sample size N = 90) and Singapore study (43 gene signature based on sample size N = 23).
  2. We selected genes associated with survival or disease-free survival using nominal p-value of 0.01.