Clinicopathologic and gene expression parameters predict liver cancer prognosis

BMC Cancer

Table 1 Using Independent HCC Studies to Validate HKU Gene Signature Identified at 0.0005 Level*

HKU Gene Signature in Normal Tissue
	Survival (1074 HKU Gene Signature) ^‡
	Overlapping Genes	Enrichment p-value
Japanese Gene Signature	33	4.8E-13
Chinese-Belgium Gene Signature	41	1.1E-13
Asia HCC Metastases Gene Signature	31	1.0E-5
Singapore Gene Signature	5	1.2E-2
	Disease Free Survival (1195 HKU Gene Signature)
	Overlapping Genes	Enrichment p-value
Japanese Gene Signature	34	1.9E-12
Chinese-Belgium Gene Signature	36	2.7E-9
Asia HCC Metastases Gene Signature	36	8.1E-7
Singapore Gene Signature	5	1.9E-2
HKU Gene Signature in Tumor Tissue
	Survival (660 HKU Gene Signature)
	Overlapping Genes	Enrichment p-value
Japanese Gene Signature	5	0.36
Chinese-Belgium Gene Signature	22	4.6E-7
Asia HCC Metastases Gene Signature	6	0.13
Singapore Gene Signature	1	0.11
	Disease Free Survival (2169 HKU Gene Signature)
	Overlapping Genes	Enrichment p-value
Japanese Gene Signature	6	0.12
Chinese-Belgium Gene Signature	28	1.4E-12
Asia HCC Metastases Gene Signature	20	1.6E-5
Singapore Gene Signature	1	0.27

*Herein, we compared gene signatures obtained in following studies: HKU study (sample size N = 229 for adjacent normal tissues and N = 267 for tumor tissues), Japan study (175 gene signature based on sample size N = 82), Asia HCC Metastases study (307 gene signature based on sample size N = 115), China-Belgium study (247 gene signature based on sample size N = 90) and Singapore study (43 gene signature based on sample size N = 23).
^‡We selected genes associated with survival or disease-free survival using nominal p-value of 0.01.

ISSN: 1471-2407