Figure 3

Comparative endogenous SL pattern in 4-HPR-sensitive and resistant leukemia cell lines. Cell were grown with (R cell lines) or without (CCRF-CEM) 4-HPR. Endogenous TOTAL (sum of the different fatty acid chain-length species) dhCer (A, left panel) and Cer (A, right panel) levels, as well as dhSph (B), TOTAL GluCer, and LactCer (C) levels were determined by LC/MS. Data are average ± SD of four (A, B) or two (C) independent experiments. *P < 0.05; **P < 0.01; ANOVA plus Tamhane or Bonferroni post-hoc test.