A cost-effectiveness analysis of a preventive exercise program for patients with advanced head and neck cancer treated with concomitant chemo-radiotherapy

Table 2 Input Parameters of base case and sensitivity analysis, including days of feeding substitutes, treatment success rates, aspiration probabilities, utilities and costs

Parameter	Mean	SE	Distribution	Source
Care
Days FS RB 2 months	0.760^a			4
Days FS UC 2 months	0.820			3
Days FS RB 3 months	0.370			4
Days FS UC 3 months	0.700			3
Days FS RB 12 months	0.030			4
Days FS UC 12 months	0.240			3
Success rates
CCRT	0.940^b	0.030	Beta	5
Recurrence rates	0.012^c	0.010	Beta	5
Aspiration PREP	0,027	0.015	Beta	4
Aspiration UC	0,054	0.015	Beta	Assumption
Utilities
During CCRT PREP	0.617	0.015	Beta	Assumption
During CCRT UC	0.517	0.015	Beta	3
Cured PREP	0.854	0.015	Beta	Assumption
Cured UC	0.754	0.015	Beta	3
Recurrent disease	0.517	0.015	Beta	Assumption
Costs
Hospital days NKI	€ 476	Fixed		8
Day care NKI	€ 229	Fixed		8
Feeding substitutes	€ 845	Fixed		NKI-AVL
Professional Tariff	€ 3,252	Fixed		DBC-system
CCRT	€ 31,000	Fixed		NKI-AVL
Palliative care	€ 30,000	Fixed		Assumption
Pneumonia	€ 1,904	Fixed		3, 4, 7
Sensitivity analysis
Utilities
During CCRT PREP low	0.567	0.015	Beta	Assumption
During CCRT PREP high	0.667	0.015	Beta	Assumption
Cured PREP low	0.804	0.015	Beta	Assumption
Cured PREP high	0.904	0.015	Beta	Assumption
Costs
Professional Tariff low	€ 1,214	Fixed		DBC-system
Professional Tariff high	€ 7,058	Fixed		DBC-system

PREP = preventive exercise program
UC = usual care
FS = feeding substitutes
NKI = Netherlands Cancer Institute
CCRT = concomitant chemo-radiotherapy
FS = Feeding substitutes
SE = Standard deviation
^a calculated to monthly rate
^b progression free survival probability of 50% over 5 years calculated to monthly survival rate
^c recurrence rate from 'complete remission' to recurrent disease

ISSN: 1471-2407