Survival endpoints in colorectal cancer and the effect of second primary other cancer on disease free survival

BMC Cancer

Table 3 Multivariate Cox proportional hazard models of disease-free survival (DFS) in 332 patients with colorectal cancer stages I-III treated with curative intention.

	DFSa			DFSb
	HR	95.0% CI		HR	95.0% CI
		Lower	Upper		Lower	Upper
Female	1.00			1.00
Male	0.85	0.62	0.18	0.90	0.66	1.22
Age ≤ 75 years	1.00			1.00
Age > 75 years	2.68	1.92	3.73	2.50	1.83	3.42
Elective operation	1.00			1.00
Emergency operation	1.64	0.94	2.86	2.06	1.23	3.46
Colon	1.00			1.00
Rectum	1.20	0.83	1.73	1.17	0.82	1.66
< 12 lymph nodes analysed	1.00			1.00
≥ 12 lymph nodes analysed	1.13	0.79	1.60	1.11	0.79	1.55
Stage I	1.00			1.00
Stage II	1.23	0.72	2.11	1.43	0.86	2.36
Stage III	2.52	1.49	4.27	2.25	1.35	3.74
Well-moderate tumour differentiation	1.00			1.00
Poor tumour differentiation	1.02	0.69	1.53	1.18	0.82	1.71
No vascular invasion	1.00			1.00
Vascular invasion	1.44	0.85	2.44	1.50	0.91	2.48

For DFSa only second primary same cancer was included as an event and second primary other cancer was ignored. For DFSb all second primary cancers were counted as an event.

ISSN: 1471-2407