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Table 2 Test characteristics of single and double FIT sampling for detection of screen relevant neoplasia

From: Double sampling of a faecal immunochemical test is not superior to single sampling for detection of colorectal neoplasia: a colonoscopy controlled prospective cohort study

  Single FIT   "one of two FITs+"   "two of two FITs+"   "mean of two FITs+"  
Cut-off value Sens Spec Sens Spec Sens Spec Sens Spec
Cut-off 50 47, 6% 88, 2% 54, 0% 83, 0% 43, 5% 93, 2% 52, 4% 88, 8%
N 59/124 844/957 67/124 794/957 54/124 892/957 65/124 850/957
(CI) (39-57) (86-90) (45-63) (80-85) (35-53) (91-95) (43-61) (87-91)
Cut-off 75 46, 0% 90, 5% 52, 4% 87, 4% 41, 1% 94, 4% 46, 8% 91, 3%
N 57/124 866/957 65/124 836/957 51/124 903/957 58/124 874/957
(CI) (37-55) (88-92) (43-61) (85-89) (32-50) (93-96) (38-56) (89-93)
Cut-off 100 45, 2% 92, 5% 51, 6% 89, 8% 39, 5% 95, 5% 44, 4% 92, 8%
N 56/124 885/957 64/124 859/957 49/124 914/957 55/124 888/957
(CI) (36-54) (91-94) (42-61) (88-92) (31-49) (94-9s7) (35-54) (91-94)
Cut-off 150 42, 7% 94, 6% 47, 6% 92, 2% 35, 5% 96, 8% 38, 7% 94, 1%
N 53/124 905/957 59/124 882/957 44/124 926/957 48/124 901/957
(CI) (34-52) (93-96) (39-57) (89-93) (27-45) (95-98) (30-48) (92-96)
Cut-off 200 37, 9% 95, 1% 41, 9% 93, 2% 34, 7% 97, 5% 37, 1% 96, 1%
N 47/124 910/957 52/124 892/957 43/124 933/957 46/124 920/957
(CI) (29-47) (94-96) (39-57) (91-95) (26-44) (96-98) (29-46) (95-97)
  1. Test characteristics at different cut-off values (ng/ml) of single and three strategies of double FIT sampling for detection of screen relevant neoplasia in 1081* individuals referred for colonoscopy (SRN in 124, no AA nor CRC in 957). *15 cases of late stage CRC were excluded since they were not considered screen relevant.
  2. FIT = faecal immunochemical test, SRN = screen relevant neoplasia, AA = advanced adenoma, CRC = colorectal cancer, "one of two FITs+" = at least one of both FITs above the cut-off value, "two of two FITs+" = both FITs above the cut-off value, "mean of two FITs+" = geometric mean of both FITs above the cut-off value, CI = confidence interval, sens = sensitivity, spec = specificity