| |
Single FIT
| |
"one of two FITs+"
| |
"two of two FITs+"
| |
"mean of two FITs+"
| |
|---|
|
Cut-off value
|
Sens
|
Spec
|
Sens
|
Spec
|
Sens
|
Spec
|
Sens
|
Spec
|
|---|
|
Cut-off 50
|
47, 6%
|
88, 2%
|
54, 0%
|
83, 0%
|
43, 5%
|
93, 2%
|
52, 4%
|
88, 8%
|
|
N
|
59/124
|
844/957
|
67/124
|
794/957
|
54/124
|
892/957
|
65/124
|
850/957
|
|
(CI)
|
(39-57)
|
(86-90)
|
(45-63)
|
(80-85)
|
(35-53)
|
(91-95)
|
(43-61)
|
(87-91)
|
|
Cut-off 75
|
46, 0%
|
90, 5%
|
52, 4%
|
87, 4%
|
41, 1%
|
94, 4%
|
46, 8%
|
91, 3%
|
|
N
|
57/124
|
866/957
|
65/124
|
836/957
|
51/124
|
903/957
|
58/124
|
874/957
|
|
(CI)
|
(37-55)
|
(88-92)
|
(43-61)
|
(85-89)
|
(32-50)
|
(93-96)
|
(38-56)
|
(89-93)
|
|
Cut-off 100
|
45, 2%
|
92, 5%
|
51, 6%
|
89, 8%
|
39, 5%
|
95, 5%
|
44, 4%
|
92, 8%
|
|
N
|
56/124
|
885/957
|
64/124
|
859/957
|
49/124
|
914/957
|
55/124
|
888/957
|
|
(CI)
|
(36-54)
|
(91-94)
|
(42-61)
|
(88-92)
|
(31-49)
|
(94-9s7)
|
(35-54)
|
(91-94)
|
|
Cut-off 150
|
42, 7%
|
94, 6%
|
47, 6%
|
92, 2%
|
35, 5%
|
96, 8%
|
38, 7%
|
94, 1%
|
|
N
|
53/124
|
905/957
|
59/124
|
882/957
|
44/124
|
926/957
|
48/124
|
901/957
|
|
(CI)
|
(34-52)
|
(93-96)
|
(39-57)
|
(89-93)
|
(27-45)
|
(95-98)
|
(30-48)
|
(92-96)
|
|
Cut-off 200
|
37, 9%
|
95, 1%
|
41, 9%
|
93, 2%
|
34, 7%
|
97, 5%
|
37, 1%
|
96, 1%
|
|
N
|
47/124
|
910/957
|
52/124
|
892/957
|
43/124
|
933/957
|
46/124
|
920/957
|
|
(CI)
|
(29-47)
|
(94-96)
|
(39-57)
|
(91-95)
|
(26-44)
|
(96-98)
|
(29-46)
|
(95-97)
|
- Test characteristics at different cut-off values (ng/ml) of single and three strategies of double FIT sampling for detection of screen relevant neoplasia in 1081* individuals referred for colonoscopy (SRN in 124, no AA nor CRC in 957). *15 cases of late stage CRC were excluded since they were not considered screen relevant.
-
FIT = faecal immunochemical test, SRN = screen relevant neoplasia, AA = advanced adenoma, CRC = colorectal cancer, "one of two FITs+" = at least one of both FITs above the cut-off value, "two of two FITs+" = both FITs above the cut-off value, "mean of two FITs+" = geometric mean of both FITs above the cut-off value, CI = confidence interval, sens = sensitivity, spec = specificity
