Slide ID | Injection | Invasion | m/hpf | Necrosis | Compression | Min. | NV |
---|
1 | Medium | 4 | 2 | 2 | 2 | 0 | 5 |
2 | Medium | 4 | 11 | 1 | 1 | 0 | 3 |
3 | Medium | 5 | 22 | 2 | 2 | 0 | 2 |
4 | RSV | 0 | 0 | 5 | 0 | 4 | 2 |
5 | RSV | 0 | 0 | 5 | 0 | 3 | 2 |
6 | RSV | 0 | 0 | 5 | 0 | 3 | 0 |
- Histological evaluations of RSV-injected versus medium-injected tumors (3 tumor specimens in each group) are presented. Tumor sections were stained with hematoxylin and eosin. For each tumor sample, pathologic changes were graded by a blinded, board certified veterinary pathologist (GBH) as 0 = normal, 1 = minimal, 2 = mild, 3 = moderate, 4 = moderately severe, 5 = severe. Grading criteria were based on invasion of adjacent normal tissue, necrosis, mitotic figures per 20X high power field (m/hpf*), compression of the surrounding tissue, mineralization (min§) and neovascularization (NVII).