Skip to main content

Table 1 Histopathological and clinical data

From: A novel splice variant of the stem cell marker LGR5/GPR49 is correlated with the risk of tumor-related death in soft-tissue sarcoma patients

Category Patients GPR49-mRNA level
in zmol/molecule HPRT
GPR49Δ5-mRNA level in zmol/molecule HPRT
   ≤1.07*10 -5 > 1.07*10 -5 ≤7.6*10 -6 > 7.6*10 -6
Total 77 39 38 39 38
   P = 0.429 P = 0.212
Men 35 16 19 15 20
Women 42 23 19 24 18
Tumor stage   P = 0.023* P = 0.005*
I 10 1 9 0 10
II 33 21 12 21 12
III 26 12 14 13 13
IV 8 5 3 5 3
Tumor type   P = 0.194 P = 0.166
liposarcoma 19 6 13 5 14
fibrosarcoma/malignant fibrous histiocytoma 20 9 11 11 9
neurogenic sarcoma 6 3 3 3 3
rhabdomyosarcoma/leiomyosarcoma 22 15 7 14 8
Other STS 10 6 4 6 4
Tumor resection   P = 0.377 P = 0.172
radical (R0) 51 24 27 23 28
not radical (R1) 26 15 11 16 10
Patients at follow-up      
alive 36 15 21 13 23
dead 41 24 17 26 15
Localization   P = 0.444 P = 0.207
extremities 49 25 24 26 23
thorax 6 2 4 1 5
head 1 0 1 0 1
abdomen 19 10 9 10 9
multiple 2 2 0 2 0
Metastasis   P = 0.291 P = 0.025*
M0 21 9 12 7 14
M1 29 17 12 19 10
Age of tumor onset   P = 0.218 P = 0.039*
age (mean)   59.9 55.4 61.4 53.9
Kaplan-Meier analysis   P = 0.056 P = 0.004*
mean survival (months)   50.1 ± 6.5 80.3 ± 10.7 45.8 ± 6.4 86.2 ± 10.9
Univariate Cox's Regression   P = 0.06 P = 0.006*
RR   1.8 2.5
CI   0.97-3.5 1.3-4.8
Multiv. Cox's-Regression   P = 0.12 P = 0.026*
RR   1.8 2.6
CI   0.9-4.0 1.1-6.0