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Table 1 Allelic frequencies of germline variants in MET coding sequence for CRC sibling pair cohort and those reported in dbSNP

From: Activating mutation in MET oncogene in familial colorectal cancer

Exon SNP* Change* # samples CRC sibling frequencies dbSNP allele frequencies
2 rs11762213 synonymous 160 89% GG, 11% GA 89% GG 11% GA
2 c.577C > T synonymous 169 99% CC, 1% CT Not reported
2 c.593G > A V136I 169 99.4%GG 0.6%GT Not reported
2 rs35775721 synonymous 165 88% CC 12%CT 97% CC 3% CT
2 rs55985569 E168D 165 99.4%GG 0.6%GT 99.5%GG 0.5% GT#
2 rs35776110 A320V 169 100% CC 97% CC 3% CT
2 rs77523018 M362T 169 98% TT 2% CT 98% TT 2% CT
2 rs33917957 N375S 169 100% AA 97% AA 3% AG
7 rs13223756 synonymous 161 75% AA 25% AG 67% AA 33%AG
14 rs56391007 T992I 163 95.7%CC 4.3%CT 99.3% CC 0.7%CT#
20 rs41736 synonymous 152 28% CC 54% GA 18%TT 37% CC 45% GA 18% TT
21 rs2023748 synonymous 157 26% GG 54% GA 20%AA 37% GG 45% GA 18% AA
21 rs41737 synonymous 157 26% GG 54% GA 20%AA 37% GG 45% GA 18% AA
  1. *for variants without a SNP identification number in dbSNP, the nucleotide change is noted with reference to NM_000245.2 with nucleotide 1 referring to A of the AUG initiation codon and amino acid change is noted with reference to NP_000236.2. # Minor allele frequency from 1000 Genomes in dbSNP, no frequency data available under population diversity.