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Figure 5 | BMC Cancer

Figure 5

From: Aurora kinases are expressed in medullary thyroid carcinoma (MTC) and their inhibition suppresses in vitro growth and tumorigenicity of the MTC derived cell line TT

Figure 5

Effects of the MK-0457 on Aurora kinases expression, subcellular localization, centrosome maturation and histone H3 phosphorylation in TT cells. (A) Western blot analysis of Aurora kinases protein levels in TT cells treated or not with MK-0457 (200 nM) for 48 h. For immunofluorescence experiments TT cells were treated or not for 6 h with MK-0457 (200 nM). Cells have been stained for Aurora-A and β-tubulin (A), Aurora-B and P-Histone H3 (B) or for Aurora-C and β-tubulin (C). Scale bar, 10 μm.

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