Table 2 Genotype and allele frequencies of ICOS polymorphisms and their associations with breast cancer risk

rs11889031¹

CC

248(40.92)

281(43.03)

reference

CT

286(47.19)

293(44.87)

1.104(0.872,1.398)

0.411

TT

72(11.88)

79(12.10)

1.025(0.713,1.472)

0.896

C

782(64.52)

855(65.47)

reference

T

430(35.48)

451(34.53)

1.039(0.882,1.224)

0.647

rs10932029

TT

523(85.88)

599(90.08)

reference

522(84.33)

614(90.03)

reference

CT

82(13.46)

64(9.62)

1.475(1.042,2.088)

0.029

95(15.35)

66(9.68)

1.693(1.201,2.350)

0.002

CC

4(0.66)

2(0.30)

2.348(0.427,12.904)

0.326

2(0.32)

2(0.29)

1.171(0.164,8.353)

0.875

T

1128(92.61)

1262(94.89)

reference

1139(92.00)

1294(94.87)

reference

C

90(7.39)

68(5.11)

1.490(1.076,2.063)

0.016

99(8.00)

66(5.13)

1.595(1.162,2.189)

0.004

rs4675374²

CC

136(22.48)

165(25.82)

reference

CT

320(52.89)

325(50.86)

1.193(0.907,1.571)

0.207

TT

149(24.63)

149(23.32)

1.216(0.882,1.677)

0.233

C

592(48.93)

655(51.25)

reference

T

618(51.07)

623(48.75)

1.099(0.939,1.286)

0.241

rs10183087³

AA

438 (72.16)

487(74.01)

reference

AC

154(25.37)

155(23.57)

0.909(0.702,1.177)

0.469

CC

15(2.47)

16(2.43)

0.951(0.454,1.993)

0.894

A

1030(84.84)

1129(85.79)

reference

C

184(15.16)

187(14.21)

0.998(0.826,1.158)

0.795

rs10932037⁴

CC

568(93.42)

618(94.93)

reference

CT

40(6.58)

33(5.07)

1.326(0.824,2.133)

0.245

TT

0

0

--

--

C

1176(96.71)

1269(97.47)

reference

T

40(3.29)

33(2.53)

1.315(0.823,2.100)

0.252