Table 2 Meta-Analysis of hOGG1 Ser326Cys Polymorphism and PCa
Ser326Cys polymorphism Genetic model (No. of studies) | Sample size | Analysis | Test of association | P value for heterogeneity | P value for Egger's test | ||
|---|---|---|---|---|---|---|---|
| Â | Case | Control | model | OR (95% CI) | P | Â | Â |
Overall (8) | Â | Â | Â | Â | Â | Â | Â |
Cys/Cys vs Ser/Ser | 1669 | 2155 | R | 1.06 (0.61-1.87) | 0.83 | < 0.00001 | 0.522 |
Cys/Cys vs Ser/Cys + Ser/Ser | 2584 | 3234 | R | 1.00 (0.61-1.63) | 0.99 | < 0.0001 | 0.823 |
Cys/Cys + Ser/Cys vs Ser/Ser | 2584 | 3234 | R | 1.12 (0.89-1.40) | 0.33 | 0.001 | 0.082 |
Cys vs Ser | 5168 | 6468 | R | 1.10 (0.88-1.37) | 0.41 | < 0.00001 | 0.158 |
Caucasian (3) | Â | Â | Â | Â | Â | Â | Â |
Cys/Cys vs Ser/Ser | 306 | 292 | R | 1.92 (0.32-11.43) | 0.47 | < 0.0001 | 0.661 |
Cys/Cys vs Ser/Cys + Ser/Ser | 498 | 556 | R | 1.60 (0.34-7.48) | 0.55 | 0.0004 | 0.668 |
Cys/Cys + Ser/Cys vs Ser/Ser | 498 | 556 | R | 1.50 (0.73-3.08) | 0.27 | 0.0009 | 0.057 |
Cys vs Ser | 996 | 1112 | R | 1.40 (0.70-2.78) | 0.34 | < 0.00001 | 0.251 |
Mixed (3) | Â | Â | Â | Â | Â | Â | Â |
Cys/Cys vs Ser/Ser | 1080 | 1167 | F | 0.67 (0.50-0.90) | 0.007 | 0.62 | 0.964 |
Cys/Cys vs Ser/Cys + Ser/Ser | 1626 | 1766 | F | 0.68 (0.51-0.91) | 0.008 | 0.69 | 0.920 |
Cys/Cys + Ser/Cys vs Ser/Ser | 1626 | 1766 | F | 0.90 (0.78-1.03) | 0.13 | 0.58 | 0.875 |
Cys vs Ser | 3252 | 3532 | F | 0.88 (0.78-0.98) | 0.02 | 0.54 | 0.982 |