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Table 2 Meta-Analysis of hOGG1 Ser326Cys Polymorphism and PCa

From: The hOGG1 Ser326Cys polymorphism and prostate cancer risk: a meta-analysis of 2584 cases and 3234 controls

Ser326Cys polymorphism Genetic model (No. of studies) Sample size Analysis Test of association P value for heterogeneity P value for Egger's test
  Case Control model OR (95% CI) P   
Overall (8)        
Cys/Cys vs Ser/Ser 1669 2155 R 1.06 (0.61-1.87) 0.83 < 0.00001 0.522
Cys/Cys vs Ser/Cys + Ser/Ser 2584 3234 R 1.00 (0.61-1.63) 0.99 < 0.0001 0.823
Cys/Cys + Ser/Cys vs Ser/Ser 2584 3234 R 1.12 (0.89-1.40) 0.33 0.001 0.082
Cys vs Ser 5168 6468 R 1.10 (0.88-1.37) 0.41 < 0.00001 0.158
Caucasian (3)        
Cys/Cys vs Ser/Ser 306 292 R 1.92 (0.32-11.43) 0.47 < 0.0001 0.661
Cys/Cys vs Ser/Cys + Ser/Ser 498 556 R 1.60 (0.34-7.48) 0.55 0.0004 0.668
Cys/Cys + Ser/Cys vs Ser/Ser 498 556 R 1.50 (0.73-3.08) 0.27 0.0009 0.057
Cys vs Ser 996 1112 R 1.40 (0.70-2.78) 0.34 < 0.00001 0.251
Mixed (3)        
Cys/Cys vs Ser/Ser 1080 1167 F 0.67 (0.50-0.90) 0.007 0.62 0.964
Cys/Cys vs Ser/Cys + Ser/Ser 1626 1766 F 0.68 (0.51-0.91) 0.008 0.69 0.920
Cys/Cys + Ser/Cys vs Ser/Ser 1626 1766 F 0.90 (0.78-1.03) 0.13 0.58 0.875
Cys vs Ser 3252 3532 F 0.88 (0.78-0.98) 0.02 0.54 0.982
  1. PCa = prostate cancer; OR = odds ratio; CI = confidence interval; vs = versus; R = random effect model; F = fixed effect model.